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We present a rare case of duodenal neuroendocrine neoplasms (NENs) with liver metastasis in a young male, whose liver masses were detected by US during a check\u2010up and then subsequently underwent Sonazoid\u2010CEUS examination in the outpatient department. The lesions in the liver showed rapid hyper\u2010enhancement in the arterial phase followed by early washout in the portal venous phase, finally showing a defect in the Kupffer phase, which strongly suggested metastases. The patient was promptly admitted for further examination, leading to a timely diagnosis of duodenal NENs with liver metastasis. This case highlights the importance of US and CEUS in asymptomatic liver masses in young patients.<\/jats:p>","DOI":"10.1002\/jcu.23957","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T15:41:21Z","timestamp":1742744481000},"page":"1176-1181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Value of Ultrasound and Contrast\u2010Enhanced Ultrasound in a Young Asymptomatic Patient With Duodenal Neuroendocrine Neoplasms: A Case Report"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9831-3336","authenticated-orcid":false,"given":"Huiyu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ultrasound The Third Central Hospital of Tianjin  Tianjin China"},{"name":"The Third Central Clinical College of Tianjin Medical University  Tianjin China"},{"name":"Department of Health Management, Tianjin Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Third Central Hospital of Tianjin  Tianjin China"},{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center Tianjin Institute of Hepatobiliary Disease  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Third Central Hospital of Tianjin  Tianjin China"},{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center Tianjin Institute of Hepatobiliary Disease  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanmin","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Third Central Hospital of Tianjin  Tianjin China"},{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center Tianjin Institute of Hepatobiliary Disease  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,22]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"545","article-title":"China Anti\u2010Cancer Association Guideline for Diagnosis and Treatment of Neuroendocrine Neoplasm (2022 Edition)","volume":"32","author":"Association, S","year":"2022","journal-title":"China Oncol"},{"key":"e_1_2_7_3_1","first-page":"385","article-title":"China Anti\u2010Cancer Association Guideline for the Diagnosis and Treatment of Neuroendocrine Neoplasms (Abridged Version)","volume":"50","author":"China Anti\u2010Cancer Association Committee of Neuroendocrine","year":"2023","journal-title":"CHINESE J. 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