{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T04:04:29Z","timestamp":1750219469327,"version":"3.41.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study was to develop a nomogram based on ultrasound and clinicopathological variables to evaluate the risk of non\u2010sentinel lymph node metastasis (NSLNM) in early breast cancer patients with positive sentinel lymph nodes (SLNs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on 438 breast cancer patients treated at the First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People's Hospital) between June 2017 and August 2024. Patients were randomly divided into training and testing sets in a 7:3 ratio for the development and validation of the nomogram, respectively. Multivariable logistic regression analysis was performed to determine independent predictors of non\u2010sentinel lymph node status, and a nomogram was created to assess the probability of NSLNM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SLN%, lesions, longest diameter of the mass, number of suspicious axillary lymph nodes (ALNs) on US, and level of suspicious ALNs were identified as the final independent predictors of NSLNM in multivariate logistic regression analysis. The nomogram predicting NSLNM was accurately calibrated, with an area under the curve of 0.84 for the training set and 0.82 for the testing set.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, we developed a nomogram model for predicting NSLNM based on ultrasound and clinicopathological features, which is useful for accurately assessing the risk of NSLNM in breast cancer patients and serves as a reference for clinicians when deciding how to treat ALNs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23960","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T09:00:31Z","timestamp":1742202031000},"page":"975-988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Validation of an Ultrasound and Clinicopathological Features\u2010Based Nomogram for Predicting Non\u2010Sentinel Lymph Node Metastasis in Breast Cancer Patients: A Single\u2010Center Observational Study"],"prefix":"10.1002","volume":"53","author":[{"given":"Jieyi","family":"Ping","sequence":"first","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjun","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Nanjing Drum Tower Hospital  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiazhen","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Jiangsu Cancer Hospital  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailing","family":"Zha","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwen","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoan","family":"Liu","sequence":"additional","affiliation":[{"name":"Breast Disease Center The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiafei","family":"Yu","sequence":"additional","affiliation":[{"name":"Breast Disease Center The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6832-8633","authenticated-orcid":false,"given":"Cuiying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199409000-00015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70207-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.11470"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(14)70460\u20107"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21568"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-08855-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.3759"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.03.015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5943"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2021.09.039"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21393"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(90)90020-D"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2460"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5839"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70035-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01565"},{"key":"e_1_2_9_19_1","first-page":"3670","article-title":"Doctor, What Are My Chances of Having a Positive Sentinel Node? A Validated Nomogram for Risk Estimation","volume":"25","author":"Bevilacqua J. L. B.","year":"2007","journal-title":"JCO Wolters Kluwer"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-66"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.05.020"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2012.07.011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S241641"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.07.017"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2009.05.007"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.4.368"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210437"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.21037\/gs-23-58","article-title":"Development and Validation of an Ultrasonography and Clinicopathological Features\u2010Based Nomogram for Non\u2010Sentinel Lymph Node Metastasis","volume":"12","author":"Chen Y.","year":"2023","journal-title":"Gland Surgery"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2014.02.006"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6633-0"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24469"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201021\u20105169"},{"key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.31557\/APJCP.2020.21.6.1559","article-title":"The Case to Case Comparison of Hormone Receptors and HER2 Status Between Primary Breast Cancer and Synchronous Axillary Lymph Node Metastasis","volume":"21","author":"Sujarittanakarn S.","year":"2020","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34540"},{"issue":"7","key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.21037\/qims-22-901","article-title":"The Application of Contrast\u2010Enhanced Ultrasound for Sentinel Lymph Node Evaluation and Mapping in Breast Cancer Patients","volume":"13","author":"Fan Y.","year":"2023","journal-title":"Quantitative Imaging in Medicine and Surgery"},{"issue":"8","key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s11547-024-01848-1","article-title":"Comparing Shear Wave Elastography of Breast Tumors and Axillary Nodes in the Axillary Assessment After Neoadjuvant Chemotherapy in Patients With Node\u2010Positive Breast Cancer","volume":"129","author":"Huang J. X.","year":"2024","journal-title":"La Radiologia Medica"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.23960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T10:16:21Z","timestamp":1750155381000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.23960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/jcu.23960"],"URL":"https:\/\/doi.org\/10.1002\/jcu.23960","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"type":"print","value":"0091-2751"},{"type":"electronic","value":"1097-0096"}],"subject":[],"published":{"date-parts":[[2025,3,17]]},"assertion":[{"value":"2024-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}