{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:45:54Z","timestamp":1773009954525,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170301"],"award-info":[{"award-number":["82170301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7234360"],"award-info":[{"award-number":["7234360"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Study aimed to assess fetal heart morphology and function in pregnancies with systemic lupus erythematosus (SLE) utilizing speckle tracking echocardiography (STE) and to evaluate indicators for predicting fetal subclinical cardiac damage in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study involved 99 SLE\u2010affected fetuses and 99 gestational age\u2010matched controls. The fetal cardiac morphology and function parameters were calculated using STE (FetalHQ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The absolute values of left ventricular (LV) global longitudinal strain (GLS), right ventricular (RV) GLS, LV fractional area change (FAC), and RV FAC in the SLE group were lower than those in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The 24\u2010segment fractional shortening (FS) analysis revealed significantly lower FS in the SLE group than the controls for LV segments 11\u201312 and RV segments 4\u201324. The 24\u2010segment sphericity index (SI) analysis indicated significantly lower SI in the SLE group than the controls for LV segments 1\u201324 and RV segments 1\u20138. The LV GLS (AUC\u2009=\u20090.859) and RV GLS (AUC\u2009=\u20090.841) could be considered good predictors of subclinical myocardial damage in SLE\u2010affected fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>STE indicated that fetuses in pregnant women with SLE present cardiac morphology and function that have changed compared to the controls. Further investigations are needed to evaluate STE indices such as the GLS, FAC, and 24\u2010segment FS and SI to predict fetal prognosis in pregnant women with SLE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23974","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T21:07:35Z","timestamp":1743368855000},"page":"1069-1077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of Fetal Cardiac Morphology and Function in Pregnant Women With Systemic Lupus Erythematosus Using Speckle Tracking Echocardiography"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-6155","authenticated-orcid":false,"given":"Jian","family":"Wu","sequence":"first","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease Beijing Anzhen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Ruan","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease Beijing Anzhen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hairui","family":"Wang","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease Beijing Anzhen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Gu","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease Beijing Anzhen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiancheng","family":"Han","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease Beijing Anzhen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-3516","authenticated-orcid":false,"given":"Yihua","family":"He","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Center in Fetal Heart Disease Beijing Anzhen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40930"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/AITC202006020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.042"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2013.10.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-015-0813-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5709"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.904138"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jen134"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.12.024"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.09.016"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20233"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.04.011"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12403"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2023.04.014"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14261"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00240110"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2019.09.002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.033894"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2023-0108"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15525"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv529"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.05.042"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew041"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17505"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.23974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T10:15:54Z","timestamp":1750155354000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.23974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/jcu.23974"],"URL":"https:\/\/doi.org\/10.1002\/jcu.23974","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]},"assertion":[{"value":"2024-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}