{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:13:22Z","timestamp":1754144002528,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The study explores corpus callosum malformation (CCM) using comprehensive brain Magnetic Resonance Imaging (MRI) for the assessment of associated malformations and their relation to long\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During a 7\u2010year period, all cases of CCM diagnosed via fetal MRI were retrospectively studied. Neurodevelopmental outcomes were assessed through postnatal interviews. Fetal brain imaging was performed using a 1.5\u2010T MRI scanner without sedation, focusing on CC development and associated anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 59 participants with CCM. Isolated CCM was observed in 25.4% of cases, while 74.6% presented with additional intracranial abnormalities, including cortical malformation (45.8%), periventricular nodular heterotopia (25.4%), supratentorial parenchymal signal intensity abnormality (25.4%), and sulcation delay (16.9%). Additionally, 16.9% of CCM cases were associated with non\u2010neurological anomalies, such as craniofacial malformations (8.5%) and urinary abnormalities (5.1%). In terms of pregnancy outcomes, 20.3% underwent pregnancy termination, 5.1% ended in stillbirth, 22.0% resulted in death after birth, and 52.5% resulted in live births. A significant association was observed between the coexistence of cortical malformation and poor prognosis (<jats:italic>p<\/jats:italic>\u2009=\u20090. 012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The broad spectrum of anomalies linked to CCM, along with their clinical outcomes, underscores the pivotal role of MRI in prenatal screening for fetuses diagnosed with CCM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23997","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T07:44:56Z","timestamp":1744703096000},"page":"1250-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of Associated Abnormalities and Outcome Assessment in Malformations of the Corpus Callosum Diagnosed via Fetal <scp>MRI<\/scp>: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2698-4872","authenticated-orcid":false,"given":"Behnaz","family":"Moradi","sequence":"first","affiliation":[{"name":"Advanced Diagnostic and Interventional Radiology Research Center (ADIR) Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Radiology, Yas Complex Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-6752","authenticated-orcid":false,"given":"Amirabbas","family":"Nikkhah","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2629-146X","authenticated-orcid":false,"given":"Mohammad Ali","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Advanced Diagnostic and Interventional Radiology Research Center (ADIR) Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Radiology, Amiralam Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2465-4415","authenticated-orcid":false,"given":"Soraya Saleh","family":"Gargari","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Mahdiyeh Hospital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-4985","authenticated-orcid":false,"given":"Mahboobeh","family":"Shirazi","sequence":"additional","affiliation":[{"name":"Maternal, Fetal and Neonatal Research Center, Yas Complex Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6390-7914","authenticated-orcid":false,"given":"Vahid","family":"Nikkhah","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12978"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2018.06.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100033\u20101349228"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2003.22.8.850"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/s135561771800111x"},{"issue":"1","key":"e_1_2_11_7_1","first-page":"22","article-title":"Corpus Callosum Agenesis","volume":"22","author":"Chacko A.","year":"2001","journal-title":"Saudi Medical Journal"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2021.111405"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000001815"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016\u20100445"},{"volume-title":"StatPearls","year":"2024","author":"Das J. 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