{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:05:34Z","timestamp":1757617534802,"version":"3.44.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We aimed to assess if flow reserve (FR) in low\u2010dose dobutamine stress echocardiography (DSE) could predict major cardiovascular events (MACE) 1 year after TAVI in patients with severe aortic stenosis (AS) and preserved left ventricular ejection fraction (LVEF). We also explored the relationship between FR and NYHA class, 6\u2010min walk test, left ventricular function, and quality of life (SF\u201036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The DSE protocol (<jats:italic>n<\/jats:italic>\u2009=\u200972) was performed up to 20\u2009\u03bcg\/kg\/min preoperatively, and FR was defined as \u2265\u200920% increase in stroke volume (SV). Echocardiography, walking test, and SF\u201036 were repeated at 12\u2009months follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average age was 80\u2009\u00b1\u20095\u2009years. Preoperative peak aortic valve velocity was 4.7\u2009\u00b1\u20090.6\u2009m\/s and LVEF was 65%\u2009\u00b1\u20099%. SV increased from 81\u2009\u00b1\u200919 to 92\u2009\u00b1\u200920\u2009mL during the DSE. Twenty\u2010five patients (36%) had FR. The prevalence of MACE was 13% at follow\u2010up. Patients with or without FR had no significant differences in MACE (<jats:italic>p<\/jats:italic>\u2009=\u20091.000), NYHA class (<jats:italic>p<\/jats:italic>\u2009=\u20090.375), walking distance (<jats:italic>p<\/jats:italic>\u2009=\u20090.262), left ventricular function, or quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FR in DSE could not predict long\u2010term outcomes after TAVI, and offered no additional prognostic value for this patient group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.24034","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T05:25:24Z","timestamp":1745817924000},"page":"1479-1487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Flow Reserve Does Not Predict Long\u2010Term Outcomes After Transaortic Valve Implantation in Patients With Preserved Left Ventricular Ejection Fraction"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3683-5291","authenticated-orcid":false,"given":"Marte","family":"S\u00e6vik","sequence":"first","affiliation":[{"name":"The Intervention Centre, Rikshospitalet Oslo University Hospital  Oslo Norway"},{"name":"Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Lovisenberg Diaconal Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan O.","family":"Beitnes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rikshospitalet Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Aaberge","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rikshospitalet Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per S.","family":"Halvorsen","sequence":"additional","affiliation":[{"name":"The 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