{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:31:08Z","timestamp":1782588668451,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371989"],"award-info":[{"award-number":["82371989"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the association of transforming growth factor \u03b21 (TGF\u2010\u03b21) with left ventricular geometry (LVG) and left ventricular function (LVF) in cases having essential hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study of 213 cases of essential hypertension, according to echocardiogram measurements, were split into normal geometry (NG), concentric remodeling (CR), eccentric hypertrophy (EH), and concentric hypertrophy (CH) groups. General clinical data of each patient was analyzed and office blood pressure measurements were performed. Detection of blood biochemistry and serum TGF\u2010\u03b21 content was conducted. The association of TGF\u2010\u03b21 with LVG and LVF parameters was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In contrast to the NG and CR groups, the TGF\u2010\u03b21 concentration was higher in the EH and CH groups, and it was most pronounced in the CH group. The TGF\u2010\u03b21 was positively linked to E\/e\u2032 (<jats:italic>r<\/jats:italic> =\u20090.506, <jats:italic>p<\/jats:italic> &lt;\u20090.001), whereas left ventricular global longitudinal strain (GLS) (<jats:italic>r<\/jats:italic> = \u22120.447, <jats:italic>p<\/jats:italic> &lt;\u20090.001) was negatively correlated. Moreover, serum TGF\u2010\u03b21 levels were independently linked to EH and CH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TGF\u2010\u03b21 was associated with abnormal LVG and LVF in cases of essential hypertension, indicating that it may induce LVG and LVF abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.24055","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:19:37Z","timestamp":1746850777000},"page":"1699-1706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship Between <scp>TGF<\/scp>\u2010\u03b21 and Left Ventricular Geometry and Function in Patients With Essential Hypertension"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7368-7267","authenticated-orcid":false,"given":"Ran","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Ultrasound First Hospital of Shanxi 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