{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T02:40:50Z","timestamp":1759718450284,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Multisystem inflammatory syndrome in children (MIS\u2010C) is associated with cardiac involvement in 67%\u201380% of cases. Cardiac symptoms often normalize rapidly after treatment, but few studies are available on the long\u2010term cardiac effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study evaluated the cardiac functions of 40 patients diagnosed with MIS\u2010C between August 2021 and November 2022. Conventional echocardiography (ECHO), electrocardiography (ECG), speckle tracking echocardiography (STE), and cardiac MR were performed at the time of diagnosis and 3\u2010nd 6\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 40 patients, 65% (26) were male and 35% (14) were female. The average age at diagnosis was 8.37\u2009\u00b1\u20094.59\u2009years (range 2\u201317). Systolic dysfunction was observed in 11(27.5%) patients on conventional ECHO; two patients (5%) required extracorporeal membrane oxygenation (ECMO) support. All patients showed rapid normalization of conventional ECHO findings with treatment. At the 3\u2010month follow\u2010up, no abnormalities in left ventricle ejection fraction (LVEF) and fractional shortening (LVFS) were detected on conventional ECHO, but STE revealed contraction abnormalities in the mid\u2010inferior and apical inferior regions of the two\u2010chamber view, the basal inferoseptal and mid\u2010anterolateral regions of the four\u2010chamber view, though improvement was noted compared to initial findings. At the 6\u2010month follow\u2010up, only a minimal contraction abnormality persisted in the two\u2010chamber mid\u2010inferior region. Cardiac MR performed at 1\u2009year in 8 (20%) patients revealed normal results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The cardiac effects of MIS\u2010C were found to improve rapidly with treatment. STE is a valuable tool for detecting and monitoring regional contraction abnormalities in MIS\u2010C patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.24064","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T05:19:36Z","timestamp":1747804776000},"page":"1810-1817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Long\u2010Term Cardiac Function in <scp>MIS<\/scp>\u2010C Patients Using Speckle Tracking Echocardiography"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2529-2906","authenticated-orcid":false,"given":"T\u00fclay","family":"Demircan","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Dokuz Eylul University, School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7791-0035","authenticated-orcid":false,"given":"Sedef","family":"\u00d6ks\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Tepecik Training and Research Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5889-9600","authenticated-orcid":false,"given":"Sedat","family":"Ba\u011fl\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Tepecik Training and Research Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4520-5574","authenticated-orcid":false,"given":"Bar\u0131\u015f","family":"G\u00fcven","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Tepecik Training and Research Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9722-6994","authenticated-orcid":false,"given":"Kaan","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Tepecik Training and Research Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0529-2391","authenticated-orcid":false,"given":"Cem","family":"Karadeniz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Katip Celebi University, School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6077-8717","authenticated-orcid":false,"given":"Ra\u015fit","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Tepecik Training and Research Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-364X","authenticated-orcid":false,"given":"Nazmi","family":"Narin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Katip Celebi University, School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6714-2367","authenticated-orcid":false,"given":"Ceren","family":"Sar\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology Dokuz Eylul University, School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.08.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-021-00499-w"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.049836"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951122000646"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048360"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-022-04748-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9050583"},{"key":"e_1_2_10_9_1","unstructured":"Centers for Disease Control and Prevention. \u201cInformation for Health Care Providers About Multisystem Inflammatory Syndrome in Children (MIS\u2010C).\u201d2020. 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