{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:16Z","timestamp":1786978036331,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate the role of fetal aortic isthmus (AoI) Doppler parameters in predicting adverse perinatal outcomes in pre\u2010eclampsia patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included 60 pre\u2010eclampsia patients (divided into early\u2010onset [EOPE] and late\u2010onset [LOPE] groups) and 74 controls from Ankara Etlik City Hospital. Doppler parameters\u2014such as aortic isthmus flow index (IFI), systolic\/diastolic ratio (S\/D), pulsatility index (PI), and resistive index (RI)\u2014were collected, and their associations with adverse perinatal outcomes were analyzed using ROC analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the EOPE group, gestational age, birth weight, and APGAR scores were significantly lower compared to the LOPE and control groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The EOPE group also showed significantly higher rates of NICU (neonatal intensive care unit) admission, preterm birth, respiratory distress syndrome, and need for mechanical ventilation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The cut\u2010off values for IFI (&gt;\u20091.13) and AoI S\/D (&gt;\u20097.42) were found to be significant predictors of adverse perinatal outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AoI Doppler parameters may aid in predicting adverse neonatal outcomes in pre\u2010eclampsia patients. The values of IFI, S\/D, PI, and RI show potential as useful tools in clinical management, especially in monitoring high\u2010risk pregnancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.24079","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T04:29:50Z","timestamp":1747283390000},"page":"1763-1772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fetal Aortic Isthmus Doppler Evaluation in Pre\u2010Eclampsia Patients"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2567-2850","authenticated-orcid":false,"given":"Gulsan","family":"Karabay","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology Ankara Etlik City Hospital  Ankara 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