{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:30:42Z","timestamp":1776843042331,"version":"3.51.2"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to compare the clinical, electrophysiologic, and sonographic characteristics of commonly affected peripheral nerves in suspected cases of pure neuritic leprosy (PNL) and to describe an ultrasound\u2010guided fine needle aspiration cytology (FNAC) procedure to improve diagnostic capabilities in PNL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study was carried out at Roy Neuro Care Centre, Ranchi, Jharkhand, India through revisiting charts of suspected cases of PNL from October 2022 to June 2024. The charts of individuals with a history, examination, and nerve ultrasound consistent with PNL were reviewed. We retrospectively analyzed the diagnostic steps, including the skin biopsy (which had been guided by electrophysiology and\/or nerve ultrasound) and the ultrasound\u2010guided FNAC of nerves that had been sent for histopathological examination, acid\u2010fast bacilli (AFB) staining, and polymerase chain reaction (PCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Charts of 52 patients derived from the records of those with mononeuropathy or mononeuritis multiplex suspected to have PNL during October 2022\u2013June 2024 were evaluated. The skin biopsy was diagnostic of PNL in 23 patients, while 29 patients had an inconclusive result. Those with an inconclusive result had an ultrasound\u2010guided FNAC followed by cytology and AFB staining. The review of the records of these cases revealed that in 24 (82.8%) cases there were features suggestive of PNL, while 5 patients had negative cytology and AFB staining. Three of these individuals had PCR, with a positive result in 1 (33.3%). A positive correlation was noted between the duration of illness and markers of progressive involvement of nerves, as determined by electrodiagnosis and ultrasound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nerve ultrasound and ultrasound\u2010guided nerve FNAC can assist in the early diagnosis of PNL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.24081","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:00:09Z","timestamp":1748912409000},"page":"1966-1978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High Resolution Nerve Ultrasound in the Diagnosis of Pure Neuritic Leprosy"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8010-5536","authenticated-orcid":false,"given":"Ujjawal","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Neurology Roy Neuro Care Centre  Ranchi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Panwar","sequence":"additional","affiliation":[{"name":"Department of Neurology Rotary Ambala Cancer and General Hospital  Ambala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Cartwright","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhashwati","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Pathology Orchid Medical Centre  Ranchi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshita","family":"Vaibhaw","sequence":"additional","affiliation":[{"name":"Department of Pathology Roy Neuro Care Centre  Ranchi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashi Bhushan","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Rajendra Institute of Medical Sciences  Ranchi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Sharma","sequence":"additional","affiliation":[{"name":"Stanley Browne Laboratory, TLM Community Hospital  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Rani","sequence":"additional","affiliation":[{"name":"Department of Dermatology Skin Bliss Clinic  Ranchi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itu","family":"Singh","sequence":"additional","affiliation":[{"name":"Stanley Browne Laboratory, TLM Community Hospital  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chittaranjan","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Darbhanga Medical College  Darbhanga India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000029842"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.15386\/mpr\u20101273"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12579"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256\u2010018\u20103109\u2010z"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12717"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.34.4.705"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000498"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-1081-5"},{"key":"e_1_2_12_10_1","first-page":"309","article-title":"Study of Correlation of HighResolution Ultrasonography and Ultrasonography Guided Fine Needle Aspiration Cytology in Diagnosis of Pure Neuritic Leprosy in a Tertiary Care Hospital","volume":"94","author":"Jena S.","year":"2022","journal-title":"Indian Journal of Leprosy"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117288"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12283"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw063"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.661441"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13432"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2019.06.007"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010070"},{"key":"e_1_2_12_18_1","unstructured":"Qiagen.2019.\u201cDNeasy Blood & Tissue Handbook Qiagen.\u201dhttps:\/\/www.qiagen.com."},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2024.116529"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.47276\/lr.92.3.207"},{"key":"e_1_2_12_21_1","first-page":"255","article-title":"Classification of Leprosy According to Immunity. 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