{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:44:27Z","timestamp":1781570667419,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY20H180005"],"award-info":[{"award-number":["LY20H180005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the diagnostic performance of superb microvascular imaging (SMI) versus color Doppler flow imaging (CDFI) and fine\u2010needle aspiration thyroglobulin (FNA\u2010Tg) in detecting indeterminate cervical lymph nodes (CLNs) in papillary thyroid carcinoma (PTC) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively analyzed clinical and imaging data from 74 PTC patients with indeterminate CLNs undergoing FNA biopsy and Tg measurement. Analyses included: (1) univariate comparison of benign versus malignant CLNs; (2) Spearman correlation between imaging features and pathological findings; and (3) receiver operating characteristic curve assessment of diagnostic accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 43 benign and 31 malignant CLNs, significant differences were observed in gender (<jats:italic>p<\/jats:italic>\u2009=\u20090.026), age (<jats:italic>p<\/jats:italic>\u2009=\u20090.041), FNA\u2010Tg levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and diagnostic outcomes for CDFI (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) and SMI (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). FNA\u2010Tg (<jats:italic>r<\/jats:italic>\u2009=\u20090.946), SMI (<jats:italic>r<\/jats:italic>\u2009=\u20090.707), and CDFI (<jats:italic>r<\/jats:italic>\u2009=\u20090.403) correlated with pathology (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). FNA\u2010Tg showed superior accuracy (AUC\u2009=\u20090.977) versus SMI (AUC\u2009=\u20090.856) and CDFI (AUC\u2009=\u20090.704). SMI detected more vessels than CDFI in benign (2.00 vs. 1.00) and malignant nodes (3.00 vs. 2.00) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with higher overall counts (2.53\u2009\u00b1\u20091.47 vs. 1.50\u2009\u00b1\u20091.13, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SMI outperformed CDFI in microvascular visualization for indeterminate CLNs in PTC. Although FNA\u2010Tg remained the most accurate diagnostic method, SMI served as a valuable noninvasive alternative, especially when FNA\u2010Tg was contraindicated or inaccessible.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.24087","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T05:00:03Z","timestamp":1747803603000},"page":"1801-1809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Novel Noninvasive Approach for Evaluating Suspicious Cervical Lymph Nodes in Papillary Thyroid Carcinoma\u2014Superb Microvascular Imaging"],"prefix":"10.1002","volume":"53","author":[{"given":"Li\u2010long","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Ultrasound in Medicine, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5668-5625","authenticated-orcid":false,"given":"Ling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010li","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3574-7932","authenticated-orcid":false,"given":"Shi\u2010yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-018-9536-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010016\u20105625\u20101"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.213303"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2004.14.959"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15171"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2010.220"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15441"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23068"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14654"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20964"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.3360"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1098"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21448"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2021.0713"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12173"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13103"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/ad11a2"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1182259"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15008"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.05.083"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.7.857"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.230006"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12102839"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30115-7"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2020.11.004"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1029936"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-200909"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07263-5"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.0515"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12029"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15010"},{"key":"e_1_2_11_34_1","first-page":"429","article-title":"Angiogenic and Lymphangiogenic Profiles in Histological Variants of Papillary Thyroid Carcinoma","volume":"127","author":"Skuletic V.","year":"2017","journal-title":"Polish Archives of Internal Medicine"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2012.53.1.126"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23210"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.14366\/usg.22218"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15205035"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-231860"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2021.101666"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-022-02573-7"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11164929"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2019.0755"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2015.12.011"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-018-9547-2"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ18-0558"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.911695"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.24087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T02:22:46Z","timestamp":1759717366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.24087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/jcu.24087"],"URL":"https:\/\/doi.org\/10.1002\/jcu.24087","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,21]]},"assertion":[{"value":"2025-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}