{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:12:49Z","timestamp":1771632769917,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background\/Aims<\/jats:title><jats:p>Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by fibrosis, vascular abnormalities, and immune system activation, often leading to significant cardiac involvement and high mortality. Interstitial lung disease (ILD) is a common complication in SSc, potentially exacerbating cardiac dysfunction. This study aimed to evaluate cardiac function using speckle\u2010tracking echocardiography (STE) and determine the impact of ILD on 5\u2010year mortality in SSc patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective cohort study, 68 SSc patients were divided into two groups based on the presence of ILD, assessed by thoracic computed tomography (CT): ILD group (<jats:italic>n<\/jats:italic>\u2009=\u200932) and non\u2010ILD group (<jats:italic>n<\/jats:italic>\u2009=\u200936). Both conventional echocardiography and STE were performed to assess cardiac function, with left ventricular global longitudinal strain (LV GLS) and right ventricular global longitudinal strain (RV GLS) as primary measures. Five\u2010year mortality data were collected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ILD group exhibited significantly lower LV GLS (\u221215.62%\u2009\u00b1\u20092.74%) and RV GLS (\u221216.46%\u2009\u00b1\u20094.38%) compared to the non\u2010ILD group (\u221218.01%\u2009\u00b1\u20092.73%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001 and \u221220.22%\u2009\u00b1\u20094.30%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001, respectively). Atrial strain parameters, including both left and right atrial reservoir and contractile strain, were significantly impaired in the ILD group. Five\u2010year all\u2010cause mortality was significantly higher in the ILD group (46.87%) compared to the non\u2010ILD group (19.44%, <jats:italic>p<\/jats:italic>\u2009=\u20090.016). Multivariate logistic regression identified age (OR\u2009=\u20091.120, 95% CI: 1.022\u20131.226, <jats:italic>p<\/jats:italic>\u2009=\u20090.015) and RV GLS (OR\u2009=\u20090.686, 95% CI: 0.550\u20130.856, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) as independent predictors of mortality. RV GLS predicted 5\u2010year mortality with a sensitivity of 86.4% and a specificity of 80.4% at a cut\u2010off value of \u221217.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SSc patients with ILD exhibit significant cardiac dysfunction and higher 5\u2010year mortality compared to those without ILD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.24094","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T03:25:54Z","timestamp":1748489154000},"page":"1838-1845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiac Dysfunction and 5\u2010Year Mortality in Patients With Systemic Sclerosis and Interstitial Lung Disease: A Speckle\u2010Tracking Echocardiography Study"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-9557","authenticated-orcid":false,"given":"Murat","family":"Demirci","sequence":"first","affiliation":[{"name":"Department of Cardiology Marmara University, Pendik Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-6590","authenticated-orcid":false,"given":"Burcu","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Radiology Marmara University, Pendik Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4273-6425","authenticated-orcid":false,"given":"G\u00fcl\u00e7in","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Radiology Marmara University, Pendik Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-1212","authenticated-orcid":false,"given":"Mustafa","family":"O\u011fuz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Health Sciences University, Sultan 2. Abdulhamid Han Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7755-3370","authenticated-orcid":false,"given":"Murat","family":"S\u00fcnb\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Cardiology Marmara University, Pendik Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0498-7709","authenticated-orcid":false,"given":"Nurten","family":"Sayar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Marmara University, Pendik Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22547"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu167"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2397198317747441"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020587"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013405"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.11.015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23041"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990555"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14214"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-014-4113-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.02.015"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487318786315"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-022-10214-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2018.06.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0b013e3181fbf8c1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000535"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2019.87619"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjopen\/oeae023"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/204748732091659132306757"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0286423"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204424"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2016.11.004"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.24094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T02:20:48Z","timestamp":1759717248000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.24094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/jcu.24094"],"URL":"https:\/\/doi.org\/10.1002\/jcu.24094","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,29]]},"assertion":[{"value":"2024-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}