{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T19:08:36Z","timestamp":1776452916393,"version":"3.51.2"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012543","name":"Shanghai Science and Technology Development Foundation","doi-asserted-by":"publisher","award":["22Y11911500"],"award-info":[{"award-number":["22Y11911500"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study sought to design and verify a nomogram that utilizes ultrasonographic and clinical indicators to differentiate between intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From November 2022 to September 2024, 136 patients with confirmed ICC or HCC were enrolled and randomly assigned to training and validation groups in a 7:3 ratio. Preoperative B\u2010mode ultrasound, contrast\u2010enhanced ultrasound, two\u2010dimensional shear wave elastography features, and clinical indicators were retrieved and compared. Least Absolute Shrinkage and Selection Operator regression and multivariate logistic regression analysis were used to identify independent factors and develop a predictive nomogram. The model's evaluation focused on discrimination, calibration, and clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant predictive factors for ICC include a history of hepatitis, levels of alpha\u2010fetoprotein and carbohydrate antigen 19\u20139, rim\u2010like arterial phase hyperenhancement, and the stiffness ratio between the lesion and liver parenchyma. With AUC values of 0.987 (95% CI: 0.969, 1.000) for the training set and 0.926 (95% CI: 0.813, 1.000) for the validation set, the nomogram exhibited strong differentiation capabilities between the two entities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The nomogram combining multimodal indicators achieved high AUC values in both the validation and test sets (AUC\u2009=\u20090.926\u20130.987), demonstrating robust diagnostic accuracy for distinguishing ICC from HCC. This tool could aid in clinical decision\u2010making for these challenging diagnoses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70047","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T02:10:37Z","timestamp":1756260637000},"page":"126-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Predictive Model Study on Differentiating Intrahepatic Cholangiocarcinoma From Hepatocellular Carcinoma Using Contrast\u2010Enhanced Ultrasound, Shear Wave Elastography, and Clinical Feature\u2010Based Nomogram"],"prefix":"10.1002","volume":"54","author":[{"given":"Lu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Ultrasound Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Huashan Hospital, 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