{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:24:58Z","timestamp":1772987098080,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to quantify the O\u2010RADS classification using the ultrasound scoring method (USM) and explore its clinical application value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 205 patients with adnexal tumors (unilateral or bilateral), corresponding to 244 tumor cases, admitted to our hospital from 2018 to 2023. This cohort included 100 patients with malignant tumors (122 malignant lesions, comprising 34 borderline tumors, and 6 malignant tumors of the fallopian tubes) and 105 patients with benign tumors (122 benign lesions). All cases were confirmed by preoperative ultrasound examination and postoperative pathology. A senior ultrasound physician performed the O\u2010RADS classification, while another ultrasound physician applied the USM. The scores were manually assigned, and the sensitivity, specificity, and area under the curve (AUC) of the USM and O\u2010RADS classification in the differential diagnosis of adnexal tumors were determined through ROC curve analysis. The Delong test was used in R to compare the diagnostic performance of the two diagnostic methods. The optimal range of scores between different categories of O\u2010RADS was calculated using by ROC curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sensitivity, specificity, and AUC of the USM (when the optimal cut\u2010off value was\u2009\u2265\u200914 points) in the differential diagnosis of adnexal tumors were 0.951, 0.877, and 0.975 (95% CI: 0.960\u20130.990). The sensitivity, specificity, and AUC of O\u2010RADS classification (when the optimal cut\u2010off value was \u2265\u20094 categories) in the differential diagnosis of adnexal tumors were 0.984, 0.887, and 0.973 (95% CI: 0.955\u20130.992). The AUC comparison between O\u2010RADS classification and USM revealed no statistically significant difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.87,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both the USM and the O\u2010RADS classification exhibit high diagnostic efficacy in the differential diagnosis of adnexal tumors. The quantification of O\u2010RADS categories using the USM provides a more intuitive and convenient approach, suitable for ultrasound physicians at all levels. This method demonstrates strong generalizability and can effectively guide clinical diagnosis and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70092","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:26:02Z","timestamp":1760171162000},"page":"564-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Analysis of the O\u2010\n                    <scp>RADS<\/scp>\n                    Classification Using Ultrasound Scoring Method (\n                    <scp>USM<\/scp>\n                    ) and Its Application Significance"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5533-7944","authenticated-orcid":false,"given":"Ju","family":"Lu","sequence":"first","affiliation":[{"name":"Ultrasound Diagnosis Department Maternal and Child Health Hospital of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3677-7992","authenticated-orcid":false,"given":"Chen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Ultrasound Diagnosis Department Maternal and Child Health Hospital of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, the Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanduo","family":"Gao","sequence":"additional","affiliation":[{"name":"Ultrasound Diagnosis Department Maternal and Child Health Hospital of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai","family":"Xu","sequence":"additional","affiliation":[{"name":"Ultrasound Diagnosis Department Maternal and Child Health Hospital of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuqin","family":"Ji","sequence":"additional","affiliation":[{"name":"Ultrasound Diagnosis Department Maternal and Child Health Hospital of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Fan","sequence":"additional","affiliation":[{"name":"Ultrasound Diagnosis Department Maternal and Child Health Hospital of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Huang","sequence":"additional","affiliation":[{"name":"Ultrasound Diagnosis Department Maternal and Child Health Hospital of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lipeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6199-0052","authenticated-orcid":false,"given":"Sheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Ultrasound Diagnosis Department Maternal and Child Health Hospital of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(90)90020-D"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9012"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019191150"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5920"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13878"},{"key":"e_1_2_10_7_1","first-page":"1","volume-title":"Ultrasound Diagnosis (Third Edition)","author":"Chang C.","year":"2013"},{"issue":"3","key":"e_1_2_10_8_1","first-page":"312","article-title":"Chinese Expert Consensus on Benign and Malignant Risk Assessment Methodology for Ovarian Tumors (2024 Edition)","volume":"40","author":"Chinese Medical Association Clinical Pharmacy Branch","year":"2024","journal-title":"Chinese Journal of Practical Gynecology and Obstetrics"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2019.02.001"},{"issue":"6","key":"e_1_2_10_10_1","first-page":"1089","article-title":"A Pilot Study on Real\u2010Time Transvaginal Uhrasonographic Elastography of Cystic Ovarian Lesions","volume":"137","author":"Ciledag N.","year":"2013","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1997.4705"},{"issue":"10","key":"e_1_2_10_12_1","first-page":"1187","article-title":"Prognosis and Ultrasound Characteristics of Complex Ovarian Cysts in Neonates","volume":"39","author":"Fang Y. 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