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This involves pelvic ultrasound and sonohysterography, followed by ultrasound\u2010guided endometrial aspiration with the same catheter. The aspirated specimens are sent for histological analysis, and in difficult or inconclusive cases, immunohistochemistry (IHC) is performed to refine the diagnosis. In this manuscript, we present a case demonstrating the utility of ultrasound\u2010guided endometrial aspiration supported by IHC. This method should be considered in the evaluation of focal endometrial lesions and\/or persistent endometrial bleeding.<\/jats:p>","DOI":"10.1002\/jcu.70120","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T05:34:45Z","timestamp":1762234485000},"page":"731-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasound\u2010Guided Endometrial Aspiration and Immunohistochemistry for Detecting Focal Metastatic Cancer"],"prefix":"10.1002","volume":"54","author":[{"given":"Maryann","family":"Kwa","sequence":"first","affiliation":[{"name":"NYU Perlmutter Cancer Center, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rouzan G.","family":"Karabakhtsian","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York 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