{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:06:53Z","timestamp":1783933613470,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore the diagnostic value of miR\u2010454\u20103p combined with Color Doppler ultrasonography (CDUS) in BC, hoping to provide new insights for breast cancer (BC) diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 205 female BC patients, 80 patients with benign breast diseases, and 50 healthy females were recruited. Serum miR\u2010454\u20103p levels were measured by RT\u2010qPCR, and all subjects underwent ultrasonic examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      BC patients had significantly higher rates of irregular morphology, unclear boundaries, spiculations, shadowing, microcalcifications, aspect ratio \u2265\u20091, and blood flow grades II\u2013III. Blood flow characteristics (RI, PI, and\n                      <jats:italic>V<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      ) were also notably elevated in BC compared to benign cases. miR\u2010454\u20103p is significantly upregulated in both benign and BC groups. In BC patients, the expression levels of miR\u2010454\u20103p were significantly elevated in those with larger tumors, higher histological grades, higher TNM stages, tumor lymph node metastasis, positive ER, and positive HER\u20102. The expression of miR\u2010454\u20103p in BC patients was significantly correlated with ultrasound boundary, spiculated margins, echogenicity, aspect ratio, blood flow grading, and blood flow characteristics (RI, PI, and\n                      <jats:italic>V<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      ). miR\u2010454\u20103p can improve the accuracy of CDUS in diagnosing BC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>miR\u2010454\u20103p has diagnostic value in BC, and its expression is significantly correlated with tumor deterioration. Combining miR\u2010454\u20103p and CDUS can improve diagnostic accuracy, providing a reference for early clinical diagnosis of BC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70133","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T07:10:56Z","timestamp":1763709056000},"page":"864-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Value of\n                    <scp>miR<\/scp>\n                    \u2010454\u20103p Combined With Color Doppler Ultrasound in Breast Cancer"],"prefix":"10.1002","volume":"54","author":[{"given":"Qian","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Ultrasound Junlian County People's Hospital  Yibin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ultrasound General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Ultrasound General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglan","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Ultrasound General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Ultrasound General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3878-9305","authenticated-orcid":false,"given":"Guangfei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1671-0898","authenticated-orcid":false,"given":"Xingzhen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology Ningbo Yinzhou No. 2 Hospital  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010021\u201006873\u20101"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM\u2010230396"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12497"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304\u2010017\u20100424\u20101"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13040738"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43141\u2010021\u201000174\u20107"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2020.5783"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21583"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.106073"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2021.04.014"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-16366-6_1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(16)00163\u20107"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.Can\u201018\u20100891"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010021\u201006194\u20108"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10071543"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094\u2010020\u201002501\u20109"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15980"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101934"},{"key":"e_1_2_11_22_1","first-page":"1","article-title":"A Modified CNN and Fuzzy AHP Based Breast Cancer Stage Detection System","author":"Mahbub T. 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