{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:06:54Z","timestamp":1783933614290,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017959","name":"Health Commission of Hebei Province","doi-asserted-by":"publisher","award":["20191434"],"award-info":[{"award-number":["20191434"]}],"id":[{"id":"10.13039\/100017959","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Bronchopulmonary dysplasia (\n BPD<\/jats:styled-content>\n ) is a risk factor for late respiratory diseases (\n LRD<\/jats:styled-content>\n ). Lung ultrasound (\n LUS<\/jats:styled-content>\n ) is a useful, radiation\u2010free tool for predicting\n BPD<\/jats:styled-content>\n , but data linking\n LUS<\/jats:styled-content>\n to late respiratory diseases is limited.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To assess the predictive value of the modified lung ultrasound score (\n mLUS<\/jats:styled-content>\n ) for late respiratory diseases in premature infants.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We retrospectively reviewed data from 140 premature infants born before 32\u2009weeks of gestation, treated for atelectasis due to\n LRD<\/jats:styled-content>\n in our\n ICU<\/jats:styled-content>\n from December 2023 to January 2025.\n LRD<\/jats:styled-content>\n was defined as a composite endpoint with operational criteria: (1) Worsening\n BPD<\/jats:styled-content>\n (need for \u2265\u200910%\n \n FiO\n 2<\/jats:sub>\n <\/jats:styled-content>\n increment or reinitiated mechanical ventilation, per 2018\n NICHD<\/jats:styled-content>\n definition); (2) Bronchiolitis (tachypnea\/wheezing\u2009+\u2009positive\n RSV RT<\/jats:styled-content>\n \u2010\n PCR<\/jats:styled-content>\n or\n LUS<\/jats:styled-content>\n \/X\u2010ray peribronchial thickening); (3) Pneumonia (fever >\u200938\u00b0C\u2009+\u2009\n CRP<\/jats:styled-content>\n >\u200920\u2009mg\/L\u2009+\u2009\n LUS<\/jats:styled-content>\n \/X\u2010ray consolidation); (4) Asthma\/reactive airway disease (\n RAW<\/jats:styled-content>\n , \u2265\u20093 bronchodilator\u2010responsive wheezing episodes); (5) Respiratory\u2010related hospitalizations (unplanned admissions for respiratory symptoms). Diagnosis was based on\n ICD<\/jats:styled-content>\n \u201010 codes, emergency notes, medication records, and imaging. Sample size calculation was performed with\n \u03b1<\/jats:italic>\n \u2009=\u20090.05, power\u2009=\u200980%, confirming 140 cases and 48 controls met requirements. Missing data (<\u20093%) were handled via multiple imputation (5 datasets), with complete\u2010case sensitivity analyses.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Multivariable logistic regression (adjusted for gestational age, birth weight, mechanical ventilation duration) showed\n mLUS<\/jats:styled-content>\n independently predicted\n LRD<\/jats:styled-content>\n (adjusted\n OR<\/jats:styled-content>\n : 1.25, 95%\n CI<\/jats:styled-content>\n : 1.10\u20131.42,\n p<\/jats:italic>\n \u2009<\u20090.001), as did traditional\n LUS<\/jats:styled-content>\n (adjusted\n OR<\/jats:styled-content>\n : 1.19, 95%\n CI<\/jats:styled-content>\n : 1.04\u20131.36,\n p<\/jats:italic>\n \u2009=\u20090.012). Model fit was good (Hosmer\u2013Lemeshow\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20097.23,\n p<\/jats:italic>\n \u2009=\u20090.495). The median\n mLUS<\/jats:styled-content>\n score was 15 (\n IQR<\/jats:styled-content>\n 9\u201321) in infants with\n LRD<\/jats:styled-content>\n versus 11 (\n IQR<\/jats:styled-content>\n 4\u201316) without (\n p<\/jats:italic>\n \u2009<\u20090.001); traditional\n LUS<\/jats:styled-content>\n was 12 (\n IQR<\/jats:styled-content>\n 6\u201316) versus 7 (\n IQR<\/jats:styled-content>\n 4\u20139) (\n p<\/jats:italic>\n \u2009<\u20090.001). The\n mLUS<\/jats:styled-content>\n had an area under the receiver operating characteristic (\n ROC<\/jats:styled-content>\n ) curve (\n AUC<\/jats:styled-content>\n ) of 0.789 (95%\n CI<\/jats:styled-content>\n 0.731\u20130.847), sensitivity 78.5%, specificity 57.2% (cutoff: 14).\n DeLong<\/jats:styled-content>\n test confirmed\n mLUS AUC<\/jats:styled-content>\n was higher than traditional\n LUS<\/jats:styled-content>\n (0.726, 95%\n CI<\/jats:styled-content>\n 0.658\u20130.794;\n p<\/jats:italic>\n \u2009=\u20090.032). Spearman correlation between scores was 0.82 (\n p<\/jats:italic>\n \u2009<\u20090.001), and\n mLUS<\/jats:styled-content>\n improved net reclassification improvement (\n NRI<\/jats:styled-content>\n \u2009=\u20090.28,\n p<\/jats:italic>\n \u2009=\u20090.002). Component analysis:\n mLUS AUC<\/jats:styled-content>\n for worsening\n BPD<\/jats:styled-content>\n was 0.812, bronchiolitis 0.765, respiratory hospitalizations 0.793; excluding asthma\/\n RAW<\/jats:styled-content>\n (sensitivity analysis) gave\n AUC<\/jats:styled-content>\n \u2009=\u20090.795 (\n p<\/jats:italic>\n \u2009=\u20090.891).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The modified lung ultrasound score is significantly linked to advanced respiratory disease in premature infants, demonstrating important clinical relevance.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcu.70139","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:20:59Z","timestamp":1764220859000},"page":"915-923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictive Value of Modified Lung Ultrasound Score for Late Respiratory Diseases in Premature Infants: A Retrospective Cohort Analysis"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2438-4129","authenticated-orcid":false,"given":"Shuang","family":"Zheng","sequence":"first","affiliation":[{"name":"Neonatology Department The Fourth Hospital of Shijiazhuang Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4709-6577","authenticated-orcid":false,"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neurology Department Hebei General Hospital Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5477-6402","authenticated-orcid":false,"given":"Yanan","family":"Gao","sequence":"additional","affiliation":[{"name":"Obstetrical Department The Fourth Hospital of Shijiazhuang Shijiazhuang Hebei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9443-3345","authenticated-orcid":false,"given":"Huifen","family":"Chen","sequence":"additional","affiliation":[{"name":"Neonatology Department The Fourth Hospital of Shijiazhuang Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1872-4834","authenticated-orcid":false,"given":"Sudan","family":"Liu","sequence":"additional","affiliation":[{"name":"Neonatology Department The Fourth Hospital of Shijiazhuang Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-0757-3"},{"issue":"1","key":"e_1_2_12_3_1","article-title":"An Investigation of the Needs of Saudi Parents of Preterm Infants in the Neonatal Intensive Care Unit","volume":"11","author":"Alsaiari E. 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