{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:06:58Z","timestamp":1783933618029,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We conducted a focused review of prenatally diagnosed apparently isolated septum pellucidum agenesis with available follow\u2010up. Across nine series including 112 fetuses, septal optic dysplasia (SOD) was ultimately confirmed in 21 cases (18.8%), but only 43% were suspected before birth, usually on the basis of optic nerve hypoplasia, while 57% were diagnosed postnatally. Truly isolated cases generally showed favorable neurodevelopment. Our accompanying case illustrates a rare association with 15q13.3 microduplication and highlights that prenatal suspicion of SOD may also arise from endocrine\u2010related sonographic markers. These findings emphasize diagnostic challenges and the value of integrated imaging and genetics.<\/jats:p>","DOI":"10.1002\/jcu.70145","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T11:55:37Z","timestamp":1764849337000},"page":"954-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal Diagnosis of Apparently Isolated Absence of the Septum Pellucidum: Literature Review and Presentation of a Rare Association With 15q13.3 Microduplication"],"prefix":"10.1002","volume":"54","author":[{"given":"Claudiana","family":"Olivieri","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, Di Venere and Sarcone Hospitals  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Volpe","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Di Venere and Sarcone Hospitals  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Gentile","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit, Department of Human Reproductive Medicine ASL Bari  Bari Italy"},{"name":"Universit\u00e0 Degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Peschechera","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Unit, Di Venere Hospital  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4420-9324","authenticated-orcid":false,"given":"Mauro","family":"De Guglielmo","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit, Department of Human Reproductive Medicine ASL Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1492-8868","authenticated-orcid":false,"given":"Paolo","family":"Volpe","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Di Venere and Sarcone Hospitals  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8847"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2666"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5663"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2628"},{"key":"e_1_2_10_6_1","first-page":"267","article-title":"Etudes Sur Les Dysraphies Cr\u00e2nio\u2010Enc\u00e9phaliques. 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Ag\u00e9n\u00e9sie Du Septum Lucidum Avec Malformation Du Tractus Optique; La Dysplasie Septo\u2010Optique","volume":"77","author":"De Morsier G.","year":"1956","journal-title":"Schweizer Archiv f\u00fcr Neurologie, Psychiatrie = Archives Suisses de Neurologie, Psychiatrie = Archivio Svizzero di Neurologia, Psichiatria"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23759"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/EB.S186307"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5363"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.12701\/jyms.2022.00493"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15252"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.06.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003048268-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2022.07.011"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5247"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100041\u20101733985"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22018"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073818783460"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.125"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcu.70145","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:25:07Z","timestamp":1783931107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.70145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,4]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/jcu.70145"],"URL":"https:\/\/doi.org\/10.1002\/jcu.70145","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,4]]},"assertion":[{"value":"2025-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}