{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:06:53Z","timestamp":1783933613463,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate real\u2010time ultrasound\u2010guided intratumoral lauromacrogol\u2009+\u2009pingyangmycin for pediatric peripheral primitive neuroectodermal tumors (pPNET) refractory to chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five tumor lesions in three children from our institution were treated under real\u2010time ultrasound guidance. Color Doppler and contrast\u2010enhanced ultrasound assessed tumor hemodynamics and size pre\u2010 and post\u2010 injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pre\u2010injection, all tumors showed rich blood flow (mixed arteriovenous signals). Post\u2010injection contrast ultrasound revealed significantly reduced arterial\u2010phase blood supply. At 4\u2010week follow\u2010up, all five tumors showed statistically significant volume reduction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and reduced tumor\u2010related pain. No adverse reactions such as bleeding and pain occurred during injection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ultrasound\u2010guided intratumoral lauromacrogol\u2009+\u2009pingyangmycin injection effectively reduces tumor blood supply, destroys local vasculature, and shrinks tumor volume in end\u2010stage pediatric pPNET. It is a safe and effective local palliative treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70155","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T03:51:51Z","timestamp":1764820311000},"page":"935-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Percutaneous Ultrasound\u2010Guided Intratumoral Injection of Lauromacrogol and Pingyangmycin in the Treatment of Advanced\n                    <scp>pPNET<\/scp>\n                    in Children"],"prefix":"10.1002","volume":"54","author":[{"given":"Bao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology Taian 88 Hospital. China RongTong Medical Healthcare Group Co. Ltd.  Taian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangru","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Surgery Oncological Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8214-2827","authenticated-orcid":false,"given":"Jian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Surgery Oncological Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.62.03.0001"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21206"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.0696"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(197310)32:4<890::aid\u2010cncr2820320421>3.0.co;2\u2010o"},{"key":"e_1_2_12_6_1","volume-title":"Primitive Neuroectodermal Tumors","author":"Honrado C. 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