{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T20:24:38Z","timestamp":1769891078415,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Portal hypertension (PH) is a major complication of chronic liver disease (CLD) and often leads to life\u2010threatening gastrointestinal bleeding. Splenic stiffness measurement (SSM) has recently emerged as a non\u2010invasive marker for assessment of PH. However, baseline values of splenic stiffness in a healthy population remain relatively unexplored.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To determine the splenic stiffness in a cohort of the healthy population from North India and to establish reference values for future clinical applications.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This descriptive study was conducted in the Department of Radio\u2010diagnosis in a tertiary care institute in North India. Patients with known chronic liver disease, splenomegaly, focal lesions in the liver or spleen, congestive heart failure, chronic kidney disease, or portal vein thrombosis, pregnant women, and pediatric patients (<\u200918\u2009years of age) were excluded. Splenic stiffness was assessed using 2\u2010D shear wave elastography (SWE). A total of 10 elastography readings were taken per patient, and the mean value was recorded.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The study population comprised 52 males and 48 females with a M:F ratio of 1.08. In our study, mean splenic stiffness was 13.44\u2009kPa (\u00b11.96 SD) with a median of 13.5\u2009kPa. The majority of participants had SSM between 10 and 16\u2009kPa (91%). A significant difference was observed in mean SSM between men and women in our study.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study provides splenic stiffness values in a cohort of healthy population in North India and can serve as a reference for non\u2010invasive assessment of PH. Future studies should be performed focusing on multicenter trials with inter\u2010observer variability assessment and comparison across different ultrasound equipment and ethnicities.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcu.70197","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:10:21Z","timestamp":1769836221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Splenic Stiffness in a Cohort of Healthy Population Using 2\u2010D Shear Wave Ultrasound Elastography"],"prefix":"10.1002","author":[{"given":"Vikrant","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Radio\u2010Diagnosis and Imaging Government Medical College Jammu Jammu and Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaffar Aziz","family":"Mir","sequence":"additional","affiliation":[{"name":"Department of Radio\u2010Diagnosis and Imaging Government Medical College Jammu Jammu and Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6772-8835","authenticated-orcid":false,"given":"Manik","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Radio\u2010Diagnosis and Imaging Government Medical College Jammu Jammu and Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijant Singh","family":"Chandail","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Government Medical College Jammu Jammu and Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13152536"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-015-0373-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100316"},{"issue":"2","key":"e_1_2_10_5_1","first-page":"163","article-title":"Evaluation of Liver and Splenic Stiffness by Acoustic Radiation Force Impulse for Assessment of Esophageal Varices","volume":"44","author":"Jain A. K.","year":"2025","journal-title":"Indian Journal of Gastroenterology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2022.12.015"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"283","article-title":"Quantitative Elastography of Spleen in Healthy Individuals and Patients With Chronic Liver Disease: Comparison of Two Techniques","volume":"269","author":"Leung V. Y. F.","year":"2013","journal-title":"Radiology"},{"issue":"2","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4103\/jmu.jmu_171_23","article-title":"Normal Values of Spleen Stiffness in Healthy Volunteers and Effect of Meal on Liver Stiffness and Spleen Stiffness","volume":"33","author":"Luekiatphaisan N.","year":"2024","journal-title":"Journal of Medical Ultrasound"},{"issue":"3","key":"e_1_2_10_9_1","first-page":"276","article-title":"Validation of Spleen Stiffness Measurement for Screening of High\u2010Risk Esophageal Varices Among Cirrhotic Patients in Indonesia: A Single\u2010Center Cross\u2010Sectional Study","volume":"56","author":"Nababan S. H. H.","year":"2024","journal-title":"Acta Medica Indonesiana"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-016-0834-4"},{"key":"e_1_2_10_11_1","volume-title":"StatPearls [Internet]","author":"Sharma A.","year":"2023"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-024-08272-5"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcu.70197","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:10:22Z","timestamp":1769836222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.70197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":11,"alternative-id":["10.1002\/jcu.70197"],"URL":"https:\/\/doi.org\/10.1002\/jcu.70197","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"2025-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jcu.70197"}}