{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:18:24Z","timestamp":1788445104498,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["PNNR\u2010MAD\u20102022\u201012376819"],"award-info":[{"award-number":["PNNR\u2010MAD\u20102022\u201012376819"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early skeletal growth represents a critical window for lifelong bone health and is influenced by genetic, nutritional, and environmental factors. However, the assessment of bone status during infancy remains challenging due to the limited feasibility of reference densitometric techniques for longitudinal use. Radiofrequency echographic multi\u2010spectrometry (REMS) is an ultrasound\u2010based technology validated for bone mineral density (BMD) assessment in adults, but its applicability to early infancy has not yet been established. This study aimed to explore a REMS\u2010based approach for investigating femoral skeletal growth during early life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty\u2010two healthy term infants underwent femoral REMS examinations at 3 and 6\u2009months of age. Unfiltered radiofrequency ultrasound signals were analyzed using a multivariate framework combining fast Fourier transform (FFT) spectral analysis with partial least squares (PLS) regression. Body weight was used as an indirect surrogate marker of skeletal growth, with spectral features serving as predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Average power spectra stratified according to PLS\u2010inferred body weight demonstrated distinct spectral patterns between lower\u2010 and higher\u2010weight infants. The PLS\u2010based spectral model showed longitudinal consistency, preserving relative skeletal status across time points. These findings indicate that REMS\u2010derived spectral features vary systematically with growth\u2010related physiological changes during infancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>REMS\u2010derived spectral characteristics appear to be sensitive to early skeletal growth processes in infancy. Although further studies incorporating direct bone outcomes are required to disentangle the relative contributions of body size and mineralization, this work provides foundational evidence supporting the feasibility of extending REMS technology to early life. REMS may represent a promising non\u2010invasive and radiation\u2010free approach for longitudinal investigation of skeletal development in pediatric populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70261","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:15:04Z","timestamp":1777349704000},"page":"1604-1611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Femoral Skeletal Growth in Early Infancy Assessed by Radiofrequency Echographic Multi\u2010Spectrometry"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5478-5657","authenticated-orcid":false,"given":"Serafina","family":"Perrone","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, Neonatology Unit, Pietro Barilla Children's Hospital University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Beretta","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Neonatology Unit, Pietro Barilla Children's Hospital University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4464-9421","authenticated-orcid":false,"given":"Laura","family":"Cannav\u00f2","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit University Hospital of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Corica","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of Adulthood and Childhood, Unit of Pediatrics University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Aversa","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of Adulthood and Childhood, Unit of Pediatrics University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Pepe","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of Adulthood and Childhood, Unit of Pediatrics University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letteria","family":"Morabito","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of Adulthood and Childhood, Unit of Pediatrics University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elisabeth","family":"Street","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Paediatric Clinic, Pietro Barilla Children's Hospital University of Parma  Parma 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