{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:54:00Z","timestamp":1791309240702,"version":"4.3.1"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary small cell neuroendocrine carcinoma (SCNEC) of the gallbladder is exceedingly uncommon and highly malignant, typically presenting at an advanced stage with a poor prognosis. Due to its rarity and nonspecific clinical manifestations, timely diagnosis remains a major challenge in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>An 80\u2010year\u2010old woman presented with a 10\u2010day history of intermittent epigastric pain radiating to the back. Abdominal ultrasound and contrast\u2010enhanced CT revealed a gallbladder fundus mass invading adjacent hepatic segments, accompanied by multiple hepatic lesions. Ultrasound\u2010guided biopsy of a hepatic lesion confirmed SCNEC by histopathology and immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Primary gallbladder SCNEC is a rare, high\u2010grade malignancy with rapid progression and poor prognosis. This case highlights the importance of early multimodal imaging evaluation and timely histopathologic confirmation. Early recognition and multidisciplinary care are pivotal to optimizing outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70271","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T04:15:27Z","timestamp":1779077727000},"page":"2015-2018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Small Cell Neuroendocrine Carcinoma of the Gallbladder With Liver Metastases: Case Report and Narrative Review"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6557-9074","authenticated-orcid":false,"given":"Xufan","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Ultrasound First Affiliated Hospital of Yangtze University  Jingzhou Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4042-4905","authenticated-orcid":false,"given":"Feifei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Ultrasound First Affiliated Hospital of Yangtze University  Jingzhou Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Shishou People's Hospital  Shishou Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound First Affiliated Hospital of Yangtze University  Jingzhou Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"issue":"6","key":"e_1_2_7_2_1","article-title":"Small Cell Type Poorly Differentiated Neuroendocrine Cancer of the Gallbladder","volume":"17","author":"Akansha","year":"2025","journal-title":"Cureus"},{"issue":"2","key":"e_1_2_7_3_1","first-page":"255","article-title":"Percutaneous Y Biliary Stent Placement in Palliative Treatment of Type 4 Malignant Hilar Stricture","volume":"7","author":"Corvino F.","year":"2016","journal-title":"Journal of Gastrointestinal Oncology"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2018.10.051"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjae386"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0314-RA"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.34172\/aim.2023.62"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.jcrt_1366_24"},{"issue":"9","key":"e_1_2_7_9_1","article-title":"Small Cell Neuroendocrine Carcinoma of the Gallbladder: Natural History and Therapeutic Challenges","volume":"17","author":"Shah N.","year":"2025","journal-title":"Cureus"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1524974"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000039147"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcu.70271","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:31:16Z","timestamp":1791307876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.70271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,17]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jcu.70271"],"URL":"https:\/\/doi.org\/10.1002\/jcu.70271","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,17]]},"assertion":[{"value":"2026-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}