{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T07:55:05Z","timestamp":1781682905649,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>According to the most recent guidelines, uncomplicated acute appendicitis could be treated conservatively using broad\u2010spectrum antibiotics, but if radiological signs of appendix rupture are present, appendectomy should be considered as first\u2010line treatment. There is limited evidence in literature regarding the non\u2010operative management of complicated acute appendicitis, particularly in the subset of patients with Crohn's disease. Intestinal and contrast\u2010enhanced ultrasound appear pivotal to both diagnosing complications and promptly identifying the non\u2010responding patients. We describe two cases of complicated acute appendicitis, successfully treated with broad\u2010spectrum antibiotic therapy and tight monitoring with both intestinal and contrast\u2010enhanced ultrasound, in patients with Crohn's disease.<\/jats:p>","DOI":"10.1002\/jcu.70288","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T07:25:41Z","timestamp":1781681141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complicated Acute Appendicitis Conservatively Treated in Two Patients With Crohn's Disease: The Role of Intestinal Ultrasound and Contrast\u2010Enhanced Ultrasound"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4969-270X","authenticated-orcid":false,"given":"Cataletti","family":"Giovanni","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Department of Biomedical and Clinical Sciences \u201cL. Sacco\u201d Hospital, University of Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gridavilla","family":"Daniele","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Biomedical and Clinical Sciences \u201cL. Sacco\u201d Hospital, University of Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-3614","authenticated-orcid":false,"given":"Nylund","family":"Kim","sequence":"additional","affiliation":[{"name":"National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital  Bergen Norway"},{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colombo","family":"Francesco","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Biomedical and Clinical Sciences \u201cL. Sacco\u201d Hospital, University of Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danelli","family":"Piergiorgio","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Biomedical and Clinical Sciences \u201cL. Sacco\u201d Hospital, University of Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0810-4026","authenticated-orcid":false,"given":"Maconi","family":"Giovanni","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Biomedical and Clinical Sciences \u201cL. Sacco\u201d Hospital, University of Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjae089"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.01.014"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017\u2010020\u201000306\u20103"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20100824\u20106952"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015038.pub2"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000624"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010020\u201004868\u2010x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010024\u201010813\u2010y"},{"issue":"3","key":"e_1_2_13_10_1","first-page":"158","article-title":"Crohn's Disease of the Appendix With Enterocutaneous Fistula Post\u2010Appendicectomy: An Approach to Management","volume":"2","author":"Machado N. O.","year":"2010","journal-title":"North American Journal of Medical Sciences"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100043\u2010125329"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.20502"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.158"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.05.043"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.01.019"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(24)00349\u20102"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2013.12.015"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcu.70288","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T07:25:42Z","timestamp":1781681142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.70288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":16,"alternative-id":["10.1002\/jcu.70288"],"URL":"https:\/\/doi.org\/10.1002\/jcu.70288","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]},"assertion":[{"value":"2026-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jcu.70288"}}