{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:18:20Z","timestamp":1788445100301,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The placenta is an essential organ for regulating maternal\u2010fetal exchange and hormonal regulation. Mechanical properties such as tissue elasticity and hormonal markers such as pregnancy\u2010associated plasma protein A (PAPP\u2010A) and free Beta\u2010human chorionic gonadotropin (f\u2010B\u2010hCG) have been proposed as indicators of placental function, but their combined utility in predicting obstetric outcomes remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the correlation between placental hormones and placental elasticity and to assess the potential utility in predicting adverse pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective study, 134 pregnant women (16\u201321\u2009weeks' gestation) underwent placental shear wave elastography (central and peripheral regions). First trimester PAPP\u2010A and f\u2010B\u2010hCG results, maternal demographics, and pregnancy outcomes were collected. Obstetric complications were defined as gestational hypertension, gestational diabetes, intrauterine growth restriction, preterm birth, and low birth weight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Peripheral placental stiffness was significantly higher in women with complications (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043), whereas central stiffness did not differ. Maternal age and body mass index (BMI) were also higher in the complication group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005, respectively). ROC analysis identified maternal age (76.6% sensitivity and 59.8% specificity with a cut\u2010off value of 31), BMI (85.1% sensitivity and 37.9% specificity with a cut\u2010off value of 23.1), and peripheral stiffness (85.1% sensitivity and 34.5% specificity with a cut\u2010off value of 2.9 (kPa)) as moderate predictors. Analysis showed that gestational age increased the risk of complications (OR\u2009=\u20092.059,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas higher BMI paradoxically decreased it (OR\u2009=\u20090.895,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014). No significant associations were observed between PAPP\u2010A, f\u2010B\u2010hCG, and adverse outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Peripheral placental stiffness measured by shear wave elastography appears to be a promising noninvasive marker for predicting obstetric complications. Although hormonal biomarkers were not predictive in this cohort, larger multicenter studies are needed to evaluate the combined prognostic role of placental markers of biochemical and biomechanical.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70298","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:58:18Z","timestamp":1781092698000},"page":"1652-1660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation Between Placental Hormones and Placental Elasticity and the Relationship Between These Parameters and Pregnancy Outcomes"],"prefix":"10.1002","volume":"54","author":[{"given":"Raziye","family":"Torun","sequence":"first","affiliation":[{"name":"Department of Perinatology Izmir City Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8682-5537","authenticated-orcid":false,"given":"Hakan","family":"Golbasi","sequence":"additional","affiliation":[{"name":"Department of Perinatology Izmir City Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-8363","authenticated-orcid":false,"given":"Zubeyde Emiralioglu","family":"Cak\u0131r","sequence":"additional","affiliation":[{"name":"Department of Perinatology Izmir City Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevim Tuncer","family":"Can","sequence":"additional","affiliation":[{"name":"Department of Perinatology Izmir City Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Omeroglu","sequence":"additional","affiliation":[{"name":"Department of Perinatology Izmir City Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceren Saglam","family":"Purut","sequence":"additional","affiliation":[{"name":"Department of Perinatology Izmir City Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilknur","family":"Toka","sequence":"additional","affiliation":[{"name":"Department of Perinatology Izmir City Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7308-352X","authenticated-orcid":false,"given":"Ilayda Gercik","family":"Arz\u0131k","sequence":"additional","affiliation":[{"name":"Department of Perinatology Izmir City Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0723-4948","authenticated-orcid":false,"given":"Hale Ankara","family":"Aktas","sequence":"additional","affiliation":[{"name":"Department of Perinatology Izmir City Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukremin","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Department of Perinatology Izmir City Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Sengul","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Izmir Katip Celebi University Faculty of Medicine  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm\u20102020\u20100464"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.5449"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10090385"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100033\u20101335205"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102323\u20100941"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2018.09.007"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010018\u20101984\u2010x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","unstructured":"Khlibovska O. I. A. V.Boychuk Y. B.Yakymchuk andV. G.Dzhyvak.2022.Optimization of Methods for Diagnostic Placental Dysfunction in Pregnant Women.https:\/\/doi.org\/10.11603\/24116\u20104944.2022.1.13219.","DOI":"10.11603\/24116-4944.2022.1.13219"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2014.14338"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2298\/VSP180109070L"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.8078"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm\u20102024\u20100609"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.31256"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010\u20100766"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806\u20109282.20210491"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1251"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404\u2010020\u201005697\u2010x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13182894"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.08.014"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc\u20102023\u2010003324"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcu.70298","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:57:33Z","timestamp":1788443853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.70298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jcu.70298"],"URL":"https:\/\/doi.org\/10.1002\/jcu.70298","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]},"assertion":[{"value":"2025-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}