{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:54:23Z","timestamp":1791309263692,"version":"4.3.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018806","name":"Department of Science and Technology of Hubei Province","doi-asserted-by":"publisher","award":["2023BCB007"],"award-info":[{"award-number":["2023BCB007"]}],"id":[{"id":"10.13039\/501100018806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Significant differences exist in the patterns and timing of organ involvement in Tuberous sclerosis complex (TSC). We sought to analyze potential differences in multiorgan involvement between\n TSC1<\/jats:italic>\n and\n TSC2<\/jats:italic>\n genotypes based on imaging findings, thereby elucidating the disease expression profile of TSC.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This retrospective investigation encompassed 112 individuals diagnosed with tuberous sclerosis at a tertiary hospital in China between March 2020 and March 2025. Clinical presentations, imaging findings, and genetic data were analyzed to evaluate the involvement of the brain, heart, and kidneys in patients with\n TSC1<\/jats:italic>\n and\n TSC2<\/jats:italic>\n mutations.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 112 patients (median age 7.17\u2009years; 60.7% male). No significant differences were observed in cerebral and cardiac involvement between\n TSC1<\/jats:italic>\n and\n TSC2<\/jats:italic>\n mutations (\n p<\/jats:italic>\n \u2009>\u20090.05). However, patients with\n TSC2<\/jats:italic>\n mutations faced an elevated cumulative risk of renal angiomyolipoma (\n TSC2<\/jats:italic>\n : 48.5% vs.\n TSC1<\/jats:italic>\n : 11.4%,\n p<\/jats:italic>\n \u2009<\u20090.001) and renal cysts (\n TSC2<\/jats:italic>\n : 33.8% vs.\n TSC1<\/jats:italic>\n : 9.1%,\n p<\/jats:italic>\n \u2009=\u20090.003). The most frequent combined involvement patterns include brain\u2010heart and brain\u2010heart\u2010kidney involvement, while isolated brain involvement was the predominant single\u2010organ phenotype.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Multisystem imaging heterogeneity and co\u2010occurrence analysis in pediatric tuberous sclerosis complex may facilitate the prediction of disease evolution and inform long\u2010term clinical management.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcu.70310","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:34:53Z","timestamp":1781872493000},"page":"1957-1966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multisystem Imaging Features and Organ Co\u2010Occurrence in Children With Tuberous Sclerosis Complex"],"prefix":"10.1002","volume":"54","author":[{"given":"Yan","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Ultrasound Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwen","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology Wuhan Hubei China"},{"name":"Department of Ultrasound, Wuhan Children's Hospital Graduate Joint Training Base, School of Medicine Wuhan University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manli","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology Wuhan Hubei 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