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Identifying the etiology of an eye malformation is very important for the counseling and management of these patients. This case report illustrates the complexity in diagnosing apparently isolated ophthalmic anomalies, and the power of genetic evaluation in establishing the prognosis.<\/jats:p>","DOI":"10.1002\/jcu.70336","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:17:15Z","timestamp":1784175435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal Diagnosis of Fetal Microphthalmia With Coloboma"],"prefix":"10.1002","author":[{"given":"Garcia Rodriguez","family":"Raquel","sequence":"first","affiliation":[{"name":"Prenatal Diagnosis and Fetal Medicine Unit, Department of Obstetrics and Gynecology Complejo Hospitalario Universitario Insular Materno Infantil de Canarias  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-3644","authenticated-orcid":false,"given":"Garcia Delgado","family":"Raquel","sequence":"additional","affiliation":[{"name":"Prenatal Diagnosis and Fetal Medicine Unit, Department of Obstetrics and Gynecology Complejo Hospitalario Universitario Insular Materno Infantil de Canarias  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De Luis Alvarado","family":"Maria","sequence":"additional","affiliation":[{"name":"Prenatal Diagnosis and Fetal Medicine Unit, Department of Obstetrics and Gynecology Complejo Hospitalario Universitario Insular Materno Infantil de Canarias  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio Perez","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Radiodiagnosis Unit Complejo Hospitalario Universitario Insular Materno Infantil de Canarias  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a Cabrera","family":"Marrero","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Complejo Hospitalario Universitario Insular Materno Infantil de Canarias  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santana Rodriuez","family":"Alfredo","sequence":"additional","affiliation":[{"name":"Clinical Genetics Unit Complejo Hospitalario Universitario Insular Materno Infantil de Canarias. Las Palmas de Gran Canaria, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia Martin","family":"Martinez","sequence":"additional","affiliation":[{"name":"Prenatal Diagnosis and Fetal Medicine Unit, Department of Obstetrics and Gynecology Complejo Hospitalario Universitario Insular Materno Infantil de Canarias  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0864-206X","authenticated-orcid":false,"given":"Gustavo","family":"Malinger","sequence":"additional","affiliation":[{"name":"Division of OB\u2010GYN Ultrasound, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine Lis Maternity Hospital, Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/pd.1970150208","article-title":"The Development of the Fetal Eye: In Utero Ultrasonographic Measurements of the Vitreous and Lens","volume":"15","author":"Achiron R.","year":"1995","journal-title":"Prenatal Diagnosis"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/ICU.0b013e328349b004","article-title":"The Genetics of Anophthalmia and Microphthalmia","volume":"22","author":"Bardakjian T. 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