{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:08:24Z","timestamp":1784286504267,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypoxic\u2013ischemic encephalopathy (HIE) remains a leading cause of neonatal mortality and long\u2010term neurodevelopmental impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PubMed, Embase, Web of Science, and the Cochrane Library were searched from inception to the latest update for observational studies evaluating the prognostic value of aEEG and\/or cUS in term and near\u2010term neonates with HIE. The primary outcome was adverse neurodevelopmental outcome, and the secondary outcome was cerebral palsy (CP). Random\u2010effects models were applied to estimate pooled proportions and diagnostic performance metrics. Heterogeneity was assessed using the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistic, with meta\u2010regression and sensitivity analyses conducted to explore potential sources of heterogeneity and result robustness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten studies involving 901 neonates with HIE were included. The pooled proportion of adverse neurodevelopmental outcomes (NDO) was 0.44 (95% CI: 0.34\u20130.54;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200984.0%). Subgroup analyses demonstrated similar adverse outcome proportions for aEEG (0.43), cUS (0.42), and conventional EEG\u2010based patterns (0.50), with no significant between\u2010group differences. For aEEG, the pooled diagnostic odds ratio for predicting adverse NDO was 18.85 (95% CI: 7.31\u201348.65). The pooled incidence of CP was 0.02 (95% CI: 0.01\u20130.07), with low to moderate heterogeneity. Meta\u2010regression did not identify publication year or assessment timing as significant contributors to heterogeneity, and sensitivity analyses confirmed result stability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adverse NDO remain frequent in neonates with HIE. aEEG demonstrates strong prognostic value for early prediction of unfavorable NDO, while cUS provides complementary but less definitive prognostic information. Standardized assessment protocols and outcome definitions are required to improve neuroprognostication in neonatal HIE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70340","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:46:36Z","timestamp":1784285196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Cranial Ultrasound and Amplitude\u2010Integrated Electroencephalography in Predicting Neurodevelopmental Outcomes in Neonates With Hypoxic\u2013Ischemic Encephalopathy: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","author":[{"given":"Meirong","family":"Shu","sequence":"first","affiliation":[{"name":"Department of Ultrasound Haikou People's Hospital  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8095-5109","authenticated-orcid":false,"given":"Shilue","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Functional(Electroencephalography Room) Haikou People's Hospital  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Haikou People's Hospital  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Haikou People's Hospital  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Haikou People's Hospital  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxue","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Haikou People's Hospital  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhi","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Haikou People's Hospital  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1039","volume-title":"Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society","author":"Abbasi H.","year":"2020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD014967.pub2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010020\u20100782\u20100"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.01.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2020.01.014"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.70186"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440\u20101754.2000.00518.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010014\u20102945\u20109"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339631001140408120336"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.48321"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102856"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000207744"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.03.035"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000468976"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010025\u201004193\u20109"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2018.12.013"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010021\u201001425\u20108"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"F34","DOI":"10.1136\/fn.72.1.F34","article-title":"Predictive Value of Early Continuous Amplitude Integrated EEG Recordings on Outcome After Severe Birth Asphyxia in Full Term Infants","volume":"72","author":"Hellstr\u00f6m\u2010Westas L.","year":"1995","journal-title":"Archives of Disease in Childhood. 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