{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:04:06Z","timestamp":1784783046774,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Although cardiovascular disease commonly accompanies chronic kidney disease, the extent of cardiac involvement in primary nephrotic syndrome (PNS) remains insufficiently defined. The objective of this research was to investigate left atrial reservoir strain (LASr) and diastolic function in adult patients with histopathologically confirmed PNS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 75 adults with histologically confirmed PNS and 100 controls were enrolled in this study. Transthoracic echocardiography was performed on all patients, encompassing conventional Doppler, tissue Doppler imaging, and LASr assessment through speckle\u2010tracking analysis. The assessment of diastolic function was performed through measurements of the\n                      <jats:italic>E<\/jats:italic>\n                      \/\n                      <jats:italic>A<\/jats:italic>\n                      ratio and the\n                      <jats:italic>E<\/jats:italic>\n                      \/\n                      <jats:italic>e<\/jats:italic>\n                      \u2032 ratio. Associations between PNS and LASr were analyzed with multivariable linear regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LASr was significantly lower in PNS patients than in controls (37.7%\u2009\u00b1\u20096.7% vs. 45.4%\u2009\u00b1\u20097.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The PNS group also showed a mild but statistically significant difference in\n                      <jats:italic>E<\/jats:italic>\n                      \/\n                      <jats:italic>e<\/jats:italic>\n                      \u2032 (7.3\u2009\u00b1\u20091.7 vs. 6.7\u2009\u00b1\u20091.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013) and a lower\n                      <jats:italic>E<\/jats:italic>\n                      \/\n                      <jats:italic>A<\/jats:italic>\n                      ratio (1.0\u2009\u00b1\u20090.3 vs. 1.2\u2009\u00b1\u20090.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariable analysis confirmed that PNS was independently associated with lower LASr (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22124.582, 95% CI: \u22126.86 to \u22122.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adult patients with PNS demonstrate lower LASr and mild alterations in conventional diastolic indices. These findings are consistent with early subclinical cardiac remodeling and support LASr as a sensitive adjunctive marker in cardiovascular risk assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70350","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:47:50Z","timestamp":1784782070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Left Atrial Strain and Diastolic Function Parameters in Adult Primary Nephrotic Syndrome Patients"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1164-2124","authenticated-orcid":false,"given":"Murat","family":"\u00c7ap","sequence":"first","affiliation":[{"name":"Department of Cardiology University of Health Sciences Diyarbak\u0131r Gazi Ya\u015fargil Education and Research Hospital  Diyarbak\u0131r Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ne\u015fe Kanbal","family":"\u00c7ap","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Diyarbakir Selahaddin Eyyubi State Hospital  Diyarbak\u0131r Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Nephrology Dicle University School of Medicine  Diyarbak\u0131r Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2491-6593","authenticated-orcid":false,"given":"Abdurrahman","family":"Aky\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Health Sciences Diyarbak\u0131r Gazi Ya\u015fargil Education and Research Hospital  Diyarbak\u0131r 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Halil","family":"Tanbo\u011fa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Atlas University Medical School  \u0130stanbul 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