{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:52:03Z","timestamp":1785905523608,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n To evaluate the potential value of peak velocity at the vertical vein obstruction site (\n V<\/jats:italic>\n max<\/jats:sub>\n ), proximal vertical vein velocity (\n V<\/jats:italic>\n p<\/jats:sub>\n ), and their ratio (\n V<\/jats:italic>\n max<\/jats:sub>\n \/\n V<\/jats:italic>\n p<\/jats:sub>\n ) in the prenatal diagnosis of fetal total anomalous pulmonary venous connection (TAPVC) with pulmonary venous obstruction (PVO) and in early neonatal risk assessment.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a retrospective cohort study. A total of 8 fetuses with TAPVC and PVO (14 examinations), 6 fetuses with TAPVC without PVO (11 examinations), and 50 normal fetuses were enrolled. Peak velocities of the vertical vein (or pulmonary vein) were compared across the three groups. In the PVO group, the correlations between indicators such as\n V<\/jats:italic>\n max<\/jats:sub>\n ,\n V<\/jats:italic>\n min<\/jats:sub>\n ,\n V<\/jats:italic>\n mean<\/jats:sub>\n , PVVI,\n V<\/jats:italic>\n p<\/jats:sub>\n , and\n V<\/jats:italic>\n max<\/jats:sub>\n \/\n V<\/jats:italic>\n p<\/jats:sub>\n and clinical outcomes (including neonatal acidosis, hypoxemia, severity of pulmonary hypertension, and death) were analyzed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n V<\/jats:italic>\n max<\/jats:sub>\n was higher in the PVO group than in the TAPVC without PVO and normal groups (\n p<\/jats:italic>\n \u2009<\u20090.001).\n V<\/jats:italic>\n p<\/jats:sub>\n was lower in the PVO group than the corresponding pulmonary venous velocity in normal fetuses (\n p<\/jats:italic>\n \u2009<\u20090.001).\n V<\/jats:italic>\n max<\/jats:sub>\n was not significantly correlated with\n V<\/jats:italic>\n max<\/jats:sub>\n \/\n V<\/jats:italic>\n p<\/jats:sub>\n (rs\u2009=\u20090.43,\n p<\/jats:italic>\n \u2009=\u20090.126), suggesting that the ratio may provide additional hemodynamic information beyond\n V<\/jats:italic>\n max<\/jats:sub>\n alone. Lower\n V<\/jats:italic>\n p<\/jats:sub>\n was associated with acidosis, hypoxemia, more severe pulmonary hypertension, more severe obstruction, and mortality (all\n p<\/jats:italic>\n \u2009\u2264\u20090.03).\n V<\/jats:italic>\n max<\/jats:sub>\n \/\n V<\/jats:italic>\n p<\/jats:sub>\n was associated with the severity of pulmonary hypertension (\n p<\/jats:italic>\n \u2009=\u20090.045).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In this small exploratory cohort,\n V<\/jats:italic>\n p<\/jats:sub>\n and\n V<\/jats:italic>\n max<\/jats:sub>\n \/\n V<\/jats:italic>\n p<\/jats:sub>\n appeared to provide complementary information to\n V<\/jats:italic>\n max<\/jats:sub>\n in fetuses with TAPVC and PVO. These preliminary findings suggest that combined assessment of proximal and stenotic\u2010site velocities may help identify atypical obstruction and support prenatal risk stratification.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcu.70356","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:37:27Z","timestamp":1785904647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Value of the Vertical Vein Stenosis Site, Proximal Flow Velocity, and Their Ratio in Prenatal Ultrasound Diagnosis and Prognostic Assessment of Fetal TAPVC With PVO"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0651-3125","authenticated-orcid":false,"given":"Yuzhou","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Ultrasound Guangzhou Medical University Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Guangzhou Medical University Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4328-9329","authenticated-orcid":false,"given":"Shilin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Guangzhou Medical University Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Guangzhou Medical University Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Guangzhou Medical University Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Guangzhou Medical University Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Guangzhou Medical University Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Guangzhou Medical University Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Guangzhou Medical University Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"issue":"3","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/jcu.22973","article-title":"Prenatal Diagnosis of Total Anomalous Pulmonary Venous Connection: 2D and 3D Echocardiographic Findings","volume":"49","author":"Bravo\u2010Valenzuela N. 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