{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T19:24:05Z","timestamp":1787426645661,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Phyllodes tumors of the breast are rare fibroepithelial neoplasms whose pathological classification remains challenging due to marked histological heterogeneity, often complicating clinical management decisions. This study investigated whether preoperative ultrasound features correlate with pathological grade in phyllodes tumors and can serve as adjunctive information to guide diagnosis and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 78 patients with pathologically confirmed phyllodes tumors (55 benign, 22 borderline, 1 malignant) who underwent preoperative ultrasound. Two blinded breast radiologists assessed tumor characteristics using the BI\u2010RADS lexicon. Histopathological grading followed the 2019 WHO criteria. Statistical analysis included chi\u2010square tests, receiver operating characteristic (ROC) curve analysis, and interobserver agreement assessment. Minimum follow\u2010up was 12\u2009months (median, 28\u2009months; range, 12\u201348\u2009months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant differences between benign and borderline tumors were observed for maximum diameter (median, 2.7 vs. 5.0\u2009cm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), irregular shape (21.8% vs. 72.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), wavy margins (18.2% vs. 72.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), calcification (16.4% vs. 50.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), and internal anechoic\/hypoechoic areas (1.8% vs. 77.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Boundary characteristics, aspect ratio, orientation, and color Doppler flow were not discriminatory (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The optimal size cutoff was 3.55\u2009cm (AUC: 0.881; sensitivity: 82.6%; specificity: 83.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while a combined model incorporating all five features achieved superior performance (AUC: 0.924; sensitivity: 90.9%; specificity: 85.5%). The single malignant tumor measured 18\u2009cm and demonstrated all high\u2010risk features. Local recurrence occurred in 9.1% of borderline tumors (2\/22), and no benign tumors recurred during follow\u2010up. Interobserver agreement ranged from moderate to almost perfect (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      \u2009=\u20090.58\u20130.89).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Specific ultrasound features, particularly size &gt;\u20093.55\u2009cm, irregular shape, wavy margins, calcification, and internal cystic areas, correlate significantly with borderline grade in phyllodes tumors. These findings can guide clinical suspicion, prompt consideration of wider excision when wavy margins are present, and help pathologists target solid components adjacent to cystic areas, potentially improving diagnostic accuracy and reducing recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70375","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T19:21:16Z","timestamp":1787426476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound Features as Adjunctive Predictors of Pathological Grade in Phyllodes Tumors of the Breast: An Imaging\u2010Pathology Correlation Study"],"prefix":"10.1002","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Li","sequence":"additional","affiliation":[{"name":"Ultrasound Department China University of Political Science and Law Campus Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8293-6298","authenticated-orcid":false,"given":"Shumin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anplas.2024.10.003"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469\u20100705.2002.00736.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinsp.2025.100617"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444377"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.5152\/ejbh.2019.4709"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002264"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2026.1694960"},{"key":"e_1_2_13_9_1","volume-title":"StatPearls [Internet]","author":"Magny S. J.","year":"2017"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina61101883"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010025\u201002904\u20101"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.06.005"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2017.03.001"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v14.i3.102741"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14091"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15455"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112151\u201020241225\u201000871"},{"issue":"17","key":"e_1_2_13_18_1","first-page":"2368","article-title":"Study on the Diagnostic Performance of Ultrasound Habitat Imaging for the Differentiation Between Benign and Malignant Phyllodes Tumors of the Breast","volume":"29","author":"Xie D.","year":"2025","journal-title":"Chinese General Practice"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2413051470"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644\u2010025\u201000879\u20109"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2013.01.004"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcu.70375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T19:21:18Z","timestamp":1787426478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.70375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,22]]},"references-count":20,"alternative-id":["10.1002\/jcu.70375"],"URL":"https:\/\/doi.org\/10.1002\/jcu.70375","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,22]]},"assertion":[{"value":"2026-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jcu.70375"}}