{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:44:53Z","timestamp":1791798293976,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Autoamputation is a rare but severe complication of neonatal ovarian cysts. This case series describes the clinical, sonographic, and pathological characteristics of neonatal ovarian cysts that progressed to autoamputation, compared with those that did not, based on a retrospective review of 19 cysts. We aim to help clinicians suspect autoamputation when managing complex neonatal ovarian cysts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Medical records of 18 neonates (19 ovarian cysts) treated at two medical centers between January 2012 and December 2023 were reviewed. All cysts appeared complex on postnatal ultrasonography. We documented prenatal and postnatal sonographic features (cyst size, solid components, septations, fluid\u2010debris levels, calcification), timing of examinations, intraoperative findings (adhesions, autoamputation), and pathology results. Descriptive statistics and exploratory comparisons between autoamputation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099 cysts) and non\u2010autoamputation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910 cysts) groups were performed, without claims of predictive modeling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 19 complex ovarian cysts, 9 (47.3%) were confirmed autoamputated at surgery. The autoamputation group showed a longer median interval from first complex features to surgery (68 vs. 21.5\u2009days) and an older age at last postnatal ultrasound (11 vs. 1\u2009days). Intra\u2010abdominal adhesions were observed in 66.7% of autoamputation cases versus 10% of non\u2010autoamputation cases. Follicles were absent in all autoamputated cysts on pathology but present in 90% of non\u2010autoamputated cysts. Sonographic findings evolved over time: fluid\u2010debris levels became the predominant feature with increasing duration, while calcification appeared late (22.2% in the autoamputation group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Autoamputation of neonatal ovarian cysts was associated with a longer interval from first complex features to surgery, absence of follicles on pathology, and frequent intra\u2010abdominal adhesions. Sonographic features evolved over time, with fluid\u2010debris levels becoming common and calcification appearing late but with poor sonographic sensitivity. These observations may help clinicians better understand the evolution of complex neonatal ovarian cysts associated with autoamputation; however, the diagnostic and predictive value of these findings requires further validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70389","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:47:27Z","timestamp":1791794847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Sonographic Features of Neonatal Ovarian Cysts With Autoamputation"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-6753","authenticated-orcid":false,"given":"Fang","family":"Yuanlong","sequence":"first","affiliation":[{"name":"Department of Neonatal Surgery Guangdong Women and Children Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7686-2561","authenticated-orcid":false,"given":"Ay\u015fe","family":"Parlak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Bursa Uludag University Faculty of Medicine  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-315X","authenticated-orcid":false,"given":"Chen","family":"Dan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Guangdong Women and Children Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du","family":"Rui","sequence":"additional","affiliation":[{"name":"Department of Pathology Guangdong Women and Children Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gynecology Guangdong Women and Children Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Wuping","sequence":"additional","affiliation":[{"name":"Department of Neonatal Surgery Guangdong Women and Children Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Shangjie","sequence":"additional","affiliation":[{"name":"Department of Neonatal Surgery Guangdong Women and Children Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.7863\/jum.2010.29.3.497","article-title":"Complex Left Fetal Ovarian Cyst With Subsequent Autoamputation and Migration Into the Right Lower Quadrant in a Neonate: Case Report and Review of the Literature","volume":"29","author":"Amodio J.","year":"2010","journal-title":"Journal of Ultrasound in Medicine"},{"issue":"1","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/uog.16002","article-title":"Outcome of Fetal Ovarian Cysts Diagnosed on Prenatal Ultrasound Examination: Systematic Review and Meta\u2010Analysis","volume":"50","author":"Bascietto F.","year":"2017","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"4","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.7863\/jum.2006.25.4.523","article-title":"Acute Progression of a Unilateral Fetal Ovarian Cyst to Complex Bilateral Cysts Causing Acute Polyhydramnios","volume":"25","author":"Bornstein E.","year":"2006","journal-title":"Journal of Ultrasound in Medicine"},{"issue":"3","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jpedsurg.2012.07.067","article-title":"Conservative Treatment for Complex Neonatal Ovarian Cysts: A Long\u2010Term Follow\u2010Up Analysis","volume":"48","author":"Cesca E.","year":"2013","journal-title":"Journal of Pediatric Surgery"},{"issue":"10","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/pd.5754","article-title":"Prenatal Evaluation and Postnatal Outcomes of Fetal Ovarian Cysts","volume":"40","author":"Chen L.","year":"2020","journal-title":"Prenatal Diagnosis"},{"issue":"9","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1053\/jpsu.2002.35014","article-title":"Bilateral Ovarian Autoamputation in an Infant","volume":"37","author":"Corbett H. J.","year":"2002","journal-title":"Journal of Pediatric Surgery"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.1136\/bcr.07.2008.0447","article-title":"Management of Ovarian Cysts During Infancy: Autoamputation Presenting as a Possible Pitfall","volume":"2009","author":"G\u00fcven\u00e7 B. H.","year":"2009","journal-title":"BML Case Reports"},{"issue":"4","key":"e_1_2_10_9_1","first-page":"337","article-title":"Complex Fetal Ovarian Cysts Cause Problems Even After Regression","volume":"24","author":"Karaku\u015f O. Z.","year":"2014","journal-title":"European Journal of Pediatric Surgery"},{"issue":"1","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/jcu.22906","article-title":"\u201cFollow the Fallopian Tube\u201d: A Technique to Improve Sonographic Identification of Ovaries in Children","volume":"49","author":"Kitami M.","year":"2021","journal-title":"Journal of Clinical Ultrasound"},{"issue":"1","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/pd.1915","article-title":"Fetal and Neonatal Ovarian Cysts: Is Surgery Indicated","volume":"28","author":"Monnery\u2010Noch\u00e9 M. E.","year":"2008","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2214\/AJR.14.13426","article-title":"Imaging Findings of Fetal\u2010Neonatal Ovarian Cysts Complicated With Ovarian Torsion and Autoamputation","volume":"205","author":"Ozcan H. N.","year":"2015","journal-title":"AJR. American Journal of Roentgenology"},{"issue":"7","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1080\/01443615.2022.2081791","article-title":"Predictive Value of Prenatal Ultrasound in Foetal Intraabdominal Cystic Lesions and Evaluation of Perinatal Outcomes: A Single\u2010Centre Study Results","volume":"42","author":"Ozkose Z. G.","year":"2022","journal-title":"Journal of Obstetrics and Gynaecology"},{"issue":"9","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/jcu.24004","article-title":"Outcome Analysis of Fetal Ovarian Cysts: A Single Center Experience","volume":"53","author":"Pang Y.","year":"2025","journal-title":"Journal of Clinical Ultrasound"},{"issue":"11","key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00383-022-05192-1","article-title":"Laparoscopy Is a Def\u0131n\u0131t\u0131ve D\u0131agnost\u0131c Method for Auto\u2010Amputated Ovary \u0131n Infants","volume":"38","author":"Parlak A.","year":"2022","journal-title":"Pediatric Surgery International"},{"issue":"1","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00383-023-05458-2","article-title":"Ultrasonographic Features Associated With Previous Torsion and the Impact of Surgery in Managing Neonatal Ovarian Cysts: A 20\u2010Year Single\u2010Centre Retrospective Study","volume":"39","author":"Tyraskis A.","year":"2023","journal-title":"Pediatric Surgery International"},{"issue":"5","key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jpag.2013.11.012","article-title":"Neonatal Surgery for Giant Floating Abdominal Cysts in Females: Clinical and Surgical Management","volume":"27","author":"Zampieri N.","year":"2014","journal-title":"Journal of Pediatric and Adolescent Gynecology"},{"issue":"2","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1136\/archdischild-2020-318902","article-title":"Bilateral Fetal Ovarian Autoamputation","volume":"106","author":"Zhou J. L.","year":"2021","journal-title":"Archives of Disease in Childhood. Fetal and Neonatal Edition"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70389","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcu.70389","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.70389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:47:29Z","timestamp":1791794849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.70389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":17,"alternative-id":["10.1002\/jcu.70389"],"URL":"https:\/\/doi.org\/10.1002\/jcu.70389","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]},"assertion":[{"value":"2026-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jcu.70389"}}