{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:00:15Z","timestamp":1790586015347,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Frasier syndrome (FS) is a rare WT1\u2010related disorder characterized by progressive nephropathy and diffuse renal parenchymal damage on imaging. Ultrasonographic findings of end\u2010stage kidney disease in FS have rarely been documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We present the case of a 12\u2010year\u2010old boy who was diagnosed with FS, harbored a heterozygous c.1447+5G&gt;A mutation in his WT1 gene, and developed CKD Stage 5. Renal ultrasonography and non\u2010contrast CT were performed. A systematic literature review was conducted to contextualize the imaging findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Non\u2010contrast CT revealed multiple areas of abnormal density in both kidneys, which raised suspicion of Wilms tumor. Ultrasonography demonstrated multiple avascular, non\u2010encapsulated nodular hyperechoic areas on a background of diffusely abnormal parenchyma and ruled out malignant tumors. The literature review confirmed that similar findings have rarely been reported in FS patients with CKD Stage 5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings describe a distinctive end\u2010stage renal ultrasound pattern in FS. Recognition of this pattern may help clinicians avoid unnecessary invasive procedures when renal malignancy is suspected in patients with advanced CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70400","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:43:05Z","timestamp":1790584985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasonographic Features of the Kidney in Patients With Frasier Syndrome and Stage 5 Chronic Kidney Disease: A Case Report and Literature Review"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9089-6450","authenticated-orcid":false,"given":"Wei","family":"Geng","sequence":"first","affiliation":[{"name":"Abdominal Ultrasound Department The Affiliated Hospital of Qingdao University  Qingdao Shandong China"},{"name":"Department of Ultrasonic Diagnosis Qingdao Special Servicemen Recuperation Center of PLA Navy  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Li","sequence":"additional","affiliation":[{"name":"Abdominal Ultrasound Department The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Xie","sequence":"additional","affiliation":[{"name":"Abdominal Ultrasound Department The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0587-4632","authenticated-orcid":false,"given":"Jiarui","family":"Liu","sequence":"additional","affiliation":[{"name":"Abdominal Ultrasound Department The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Qilu Hospital of Shandong University (Qingdao)  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Li","sequence":"additional","affiliation":[{"name":"Abdominal Ultrasound Department The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1045-077X","authenticated-orcid":false,"given":"Chunping","family":"Ning","sequence":"additional","affiliation":[{"name":"Abdominal Ultrasound Department The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"1148","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20221096","article-title":"Radiological Features of Nephrocalcinosis, a Common but Forgotten Entity","volume":"96","author":"Aldana J. 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