{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:05:36Z","timestamp":1789535136201,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cranial ultrasound (cUS) is the first\u2010line neonatal neuroimaging modality; however, quantitative gestational age (GA)\u2010specific reference ranges for multimodal brain parenchyma parameters remain undefined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To establish GA\u2010stratified reference values for structural, hemodynamic, elastographic, volumetric, and microvascular cUS parameters in neonates without major cerebral or systemic abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cross\u2010sectional study enrolled 100 neonates without major cerebral or systemic abnormalities (GA 24\u201342\u2009weeks) across four groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925 each). Nine parameters were assessed within 24\u201372\u2009h using an Aloka Symphony 70: lateral ventricle width, grayscale echogenicity in the periventricular white matter, middle cerebral artery (MCA) peak systolic velocity (PSV), resistive index (RI), and pulsatility index (PI), periventricular white matter and basal ganglia Young's modulus, ventricle\u2010to\u2010parenchyma volume ratio (VV\/PV), and microvascular density (MVD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All nine parameters showed significant GA\u2010dependent variation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Strongest positive correlations with GA were observed for white matter stiffness (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.912) and MVD (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.896); strongest negative correlations for VV\/PV (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.790) and RI (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.738). White matter stiffness increased from 2.89 to 7.96\u2009kPa; MVD nearly tripled. Centile tables (P5\u2013P95) were generated for all parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides the first comprehensive multimodal GA\u2010specific reference ranges for neonatal brain parenchyma, potentially facilitating early detection of maturational deviations in clinical neurosonography.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70409","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:46:56Z","timestamp":1789534016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gestational Age\u2010Specific Reference Ranges for Multimodal Cranial Ultrasound Parameters of Brain Parenchyma in Neonates: A Retrospective Cross\u2010Sectional Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0449-8843","authenticated-orcid":false,"given":"Jianming","family":"Song","sequence":"first","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Putian University  Putian Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlian","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Putian University  Putian Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neonatal Intensive Care Unit Affiliated Hospital of Putian University  Putian Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Putian University  Putian Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Putian University  Putian Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neonatal Intensive Care Unit Affiliated Hospital of Putian University  Putian Fujian 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