{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:49:39Z","timestamp":1791438579125,"version":"4.3.3"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore whether ultrasound can identify findings suggestive of fetal complex congenital heart disease in highly selected high\u2010risk fetuses during the mid\u2010first trimester.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 23 highly selected high\u2010risk fetuses who related to CHD that underwent ultrasound examinations in our department between March 2015 and March 2025. Standardized scanning included mid\u2010sagittal view, transverse views of the head, upper limbs, abdomen, lower limbs, thorax, and cardiac were obtained. A transverse scan of the cardiac was performed to obtain the color Doppler and\/or gray scale four\u2010chamber view and three\u2010vessel\u2010and\u2010trachea view. Among them, six cases suspected of CHD were selected as the research objects. Ultrasound soft markers and abnormalities were recorded, and follow\u2010up was performed with 11\u201314 gestational weeks recheck ultrasound, chromosomal analysis, and pathological anatomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ultrasound soft markers were identified in six cases. Among them, nuchal translucency thickening was observed in five cases, and severe atrioventricular valve regurgitation was detected in four cases. Extracardiac abnormalities were diagnosed in five cases, including two cases of hydrops fetalis, one case each of conjoined twins, bilateral hook\u2010shaped hands, and hydrops fetalis complicated by gastroschisis. Three cases of functional single ventricle, one case of hypoplastic left heart, one case of complete atrioventricular septal defect, and one case of aortic arch malformation were suspected. Chromosomal abnormalities were present in four cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In highly selected high\u2010risk fetuses, earlier fetal echocardiographic scanning may help identify findings suggestive of complex congenital heart disease during the mid\u2010first trimester.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.70429","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:52:17Z","timestamp":1791435137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasonic Suggestive Findings of Complex Congenital Heart Diseases in Highly Selected High\u2010Risk Fetuses During Mid\u2010First Trimester: A Summary of Six Cases"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4493-8469","authenticated-orcid":false,"given":"Shuihua","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of GuangXi Zhuang Autonomous Region Guangxi Clinical Medical Research Center for Birth Defects, Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9906-0453","authenticated-orcid":false,"given":"Yinbei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of GuangXi Zhuang Autonomous Region Guangxi Clinical Medical Research Center for Birth Defects, Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6034-0822","authenticated-orcid":false,"given":"Longbin","family":"Yang","sequence":"additional","affiliation":[{"name":"Graduate School, Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7491-5894","authenticated-orcid":false,"given":"Mengfeng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of GuangXi Zhuang Autonomous Region Guangxi Clinical Medical Research Center for Birth Defects, Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0013-973X","authenticated-orcid":false,"given":"Guican","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Maternal and Child Health Hospital of GuangXi Zhuang Autonomous Region Guangxi Clinical Medical Research Center for Birth Defects, Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention and Control  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3463-5802","authenticated-orcid":false,"given":"Ang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Affiliated Hospital of Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15477"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469\u20100705.2002.00739.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735\u20101097(02)01886\u20107"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26106"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.23\u20106\u2010e373"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.037"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2685"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21921"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455947"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20844"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2792"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010022\u201004491\u20108"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23818"}],"container-title":["Journal 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