{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:49:48Z","timestamp":1792136988427,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report the case of a 16\u2010year\u2010old female with cribriform\u2010morular variant of papillary thyroid carcinoma (CMV\u2010PTC) and a confirmed germline APC mutation, with a history of childhood medulloblastoma consistent with Turcot syndrome Type 2. Ultrasound revealed bilateral, multifocal, predominantly hypoechoic nodules with mixed cystic\u2010solid components and well\u2010defined margins, without microcalcifications. The nodules grew rapidly over 2\u2009years of surveillance, prompting total thyroidectomy. Histopathology confirmed bilateral CMV\u2010PTC with capsular invasion. At age 19, the patient developed cervical lymph node and pulmonary metastases. Previous reports have described CMTC\/CMV\u2010PTC as presenting with bilateral or multifocal hypoechoic nodules, relatively well\u2010defined margins, and infrequent microcalcifications. Recognition of these features in a young patient should raise consideration of an underlying APC\u2010related syndrome and prompt genetic evaluation, even in the absence of a family history.<\/jats:p>","DOI":"10.1002\/jcu.70436","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:25:11Z","timestamp":1792135511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound Features of Adolescent Cribriform\u2010Morular Variant Papillary Thyroid Carcinoma and Its Association With\n                    <scp>APC<\/scp>\n                    Gene Syndrome: A Case Report"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0986-733X","authenticated-orcid":false,"given":"Fangting","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasound Guangdong Provincial People's Hospital, Zhuhai Hospital (Jinwan Central Hospital of Zhuhai)  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Imaging The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3842-266X","authenticated-orcid":false,"given":"Qiongzhu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Guangdong Provincial People's Hospital, Zhuhai Hospital (Jinwan Central Hospital of Zhuhai)  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingcui","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Imaging The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-0716-2505-7_2","article-title":"Assessment of Papillary Thyroid Carcinoma With Ultrasound Examination","volume":"2534","author":"Abe I.","year":"2022","journal-title":"Methods in Molecular Biology"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1007\/s00268-018-4644-4","article-title":"Cribriform\u2010Morular Variant of Papillary Thyroid Carcinoma: Clinical and Pathological Features of 30 Cases","volume":"42","author":"Akaishi J.","year":"2018","journal-title":"World Journal of Surgery"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10689-019-00146-4","article-title":"A Unique Case of Two Somatic APC Mutations in an Early Onset Cribriform\u2010Morular Variant of Papillary Thyroid Carcinoma and Overview of the Literature","volume":"19","author":"Aydemirli M. D.","year":"2020","journal-title":"Familial Cancer"},{"key":"e_1_2_10_5_1","first-page":"531","article-title":"Cribriform\u2010Morular Variant of Papillary Thyroid Carcinoma at Pediatric Age \u2010 Case Report and Review of the Literature","volume":"57","author":"Brehar A. C.","year":"2016","journal-title":"Romanian Journal of Morphology and Embryology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1111\/ans.18451","article-title":"Cribriform Morular Thyroid Carcinoma: A Recently Reclassified Entity","volume":"93","author":"Chang H. Y.","year":"2023","journal-title":"ANZ Journal of Surgery"},{"key":"e_1_2_10_7_1","first-page":"712","article-title":"Molecular Pathology of Thyroid Tumors: Essential Points to Comprehend Regarding the Latest WHO Classification","volume":"12","author":"Chiba T.","year":"2024","journal-title":"Biomedicine"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/thy.2011.0534","article-title":"Cribriform\u2010Morular Variant of Papillary Thyroid Carcinoma: Ultrasonographic and Clinical Characteristics","volume":"23","author":"Chong Y.","year":"2013","journal-title":"Thyroid"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/1066896918796946","article-title":"Cribriform\u2010Morular Variant of Papillary Thyroid Carcinoma With Poorly Differentiated Features: A Case Report With Immunohistochemical and Molecular Genetic Analysis","volume":"27","author":"Corean J.","year":"2019","journal-title":"International Journal of Surgical Pathology"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"1331271","DOI":"10.3389\/fonc.2024.1331271","article-title":"Case Report: Turcot Syndrome Type 2 in a Developing Country Within the Caribbean","volume":"14","author":"Daniel\u2010Abdool M.","year":"2024","journal-title":"Frontiers in Oncology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"6045","DOI":"10.1007\/s12070-021-02674-x","article-title":"A Case Report and Review of Literature: Cribriform\u2010Morular Variant of Papillary Carcinoma","volume":"74","author":"Dubey T.","year":"2022","journal-title":"Indian Journal of Otolaryngology"},{"key":"e_1_2_10_12_1","first-page":"59","article-title":"Changes in the Diagnosis of Thyroid Tumours in the 5th Edition of the WHO Classification of Endocrine Neoplasms","volume":"60","author":"Du\u0161kov\u00e1 J.","year":"2024","journal-title":"Ceskoslovensk\u00e1 Patologie"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00428-023-03495-9","article-title":"Cribriform Morular Thyroid Carcinoma: A Case Report With Pathological, Immunohistochemical, and Molecular Findings Suggesting an Origin From Follicular Cells (Or Their Endodermal Precursors)","volume":"482","author":"Echegoyen\u2010Silanes A.","year":"2023","journal-title":"Virchows Archiv"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000501097","article-title":"Cribriform\u2010Morular Variant of Papillary Thyroid Carcinoma Shows High Ki\u201067 Labeling Indices, Despite Its Excellent Prognosis","volume":"86","author":"Hirokawa M.","year":"2019","journal-title":"Pathobiology"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3803\/EnM.2021.974","article-title":"Clinicopathological Characteristics and Recurrence\u2010Free Survival of Rare Variants of Papillary Thyroid Carcinomas in Korea: A Retrospective Study","volume":"36","author":"Kim M.","year":"2021","journal-title":"Endocrinology and Metabolism"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.aace.2024.01.002","article-title":"A Rare Case of Persistent Multifocal Cribriform\u2010Morular Thyroid Carcinoma","volume":"10","author":"Kuenstner W.","year":"2024","journal-title":"AACE Clinical Case Reports"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"R109","DOI":"10.1530\/ERC-17-0014","article-title":"Cribriform\u2010Morular Variant of Papillary Thyroid Carcinoma: A Distinctive Type of Thyroid Cancer","volume":"24","author":"Lam A. 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