{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:03:32Z","timestamp":1788177812505,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["217065\/Z\/19\/Z"],"award-info":[{"award-number":["217065\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["MRC"],"award-info":[{"award-number":["MRC"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000883","name":"University of Bristol","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000883","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCPP Advances"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patterns of development and underlying factors explaining anxiety disorders in children and adolescents are under\u2010researched, despite their high prevalence, impact and associations with other mental disorders. We aimed to a] understand the pattern and persistence of specific anxiety disorders; b] examine differing trajectories of symptoms of specific anxiety disorders and; c] examine socio\u2010demographic and health\u2010related predictors of persistent anxiety disorder\u2010specific symptoms, across middle childhood to early adolescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The current study used data from 8122 participants in the Avon Longitudinal Study of Parents and Children birth cohort. The Development and Wellbeing Assessment questionnaire was administered to parents to capture child and adolescent anxiety total scores and DAWBA\u2010derived diagnoses. Separation anxiety, specific phobia, social anxiety, acute stress reaction, and generalized anxiety at 8, 10 and 13\u00a0years were selected. Further, we included the following socio\u2010demographic and health\u2010related predictors: sex, birth weight, sleep difficulties at 3.5\u00a0years, ethnicity, family adversity, maternal age at birth, maternal postnatal anxiety, maternal postnatal depression, maternal bonding, maternal socio\u2010economic status and maternal education.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Different anxiety disorders presented different prevalence and patterns of development over time. Further, latent class growth analyses yielded a trajectory characterized by individuals with persistent high levels of anxiety across childhood and adolescence; for specific phobia (high\u00a0=\u00a05.8%; moderate\u00a0=\u00a020.5%; low\u00a0=\u00a073.6%), social anxiety (high\u00a0=\u00a03.4%; moderate\u00a0=\u00a012.1%; low\u00a0=\u00a084.5%), acute stress reaction (high\u00a0=\u00a01.9%; low\u00a0=\u00a098.1%) and generalized anxiety (high\u00a0=\u00a05.4%; moderate\u00a0=\u00a021.7%; low\u00a0=\u00a072.9%). Finally, the risk factors associated with each of the persistent high levels of anxiety disorders were child sleeping difficulties and postnatal maternal depression and anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings show that a small group of children and young adolescents continue to suffer from frequent and severe anxiety. When considering treatment strategies for anxiety disorders in this group, children's sleep difficulties and postnatal maternal depression and anxiety need to be assessed as these may predict a more prolonged and severe course of illness.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcv2.12089","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:44:27Z","timestamp":1656117867000},"source":"Crossref","is-referenced-by-count":11,"title":["Anxiety disorders across middle childhood and early adolescence in a UK population\u2010based cohort"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4718-6768","authenticated-orcid":false,"given":"Isabel","family":"Morales\u2010Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Institute for Mental Health University of Birmingham  Birmingham UK"},{"name":"Department of Public Health Solutions Mental Health Unit Finnish Institute for Health and Welfare  Helsinki 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