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To build the foundation for a parsimonious psychopathology risk calculator while capturing the complexity and dynamic nature of the environment, the current study aimed to identify distinct risk and resilience profiles with a wide range of environmental factors guided by Bronfenbrenner's biopsychosocial ecological system theory. The association between the early\u2010mid childhood risk profiles and psychopathology in adolescence were examined. Moreover, the predictive utility of early childhood irritability was evaluated in addition to the risk profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data from Future of Families and Child Wellbeing Study a nation\u2010wide longitudinal study, were used in the latent profile analyses to identify the risk profiles with family, school, and neighborhood characteristics from 3 to 9\u00a0years old. To capture the socio\u2010environmental and cultural nuances, we extracted three subsamples, including Black\/African American (<jats:italic>n<\/jats:italic>\u00a0=\u00a02587), Hispanic\/Latinx (<jats:italic>n<\/jats:italic>\u00a0=\u00a01577), and White (<jats:italic>n<\/jats:italic>\u00a0=\u00a0776) for separate analyses. Risk profile memberships were used to predict adolescence psychopathology, including depression, anxiety, attention deficits, oppositional defiant disorder, and conduct disorder symptoms. The predictive utility of early childhood irritability above and beyond environmental risk profiles was evaluated using stepwise regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three risk profiles were identified in the Hispanic\/Latinx and Black\/African American subsamples, while four profiles were identified in White subsample. Almost all risk profile membership predicted both internalizing and externalizing psychopathology, while some profiles are predictive of externalizing symptoms only. Higher level of irritability predicted higher symptomatology in all five mental health outcomes above and beyond the environmental profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Distinct risk and resilience profiles primarily driven by parent and family characteristics were identified for all three major race\/ethnicity groups. Our findings lay the foundation for a more efficient multi\u2010tiered information gathering process in mental health clinical settings to aid the decision making for intervention and prevention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcv2.12180","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T04:59:58Z","timestamp":1686632398000},"source":"Crossref","is-referenced-by-count":5,"title":["Toward an optimized assessment of adolescent psychopathology risk: Multilevel environmental profiles and child irritability as predictors"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6844-2014","authenticated-orcid":false,"given":"Qiongru","family":"Yu","sequence":"first","affiliation":[{"name":"San Diego State University\/University of California San Diego Joint Doctoral Program in Clinical Psychology  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Psychology San Diego State University  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conner","family":"Swineford","sequence":"additional","affiliation":[{"name":"Department of Psychology San Diego State University  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nia","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Psychology San Diego State University  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigha","family":"MacNeill","sequence":"additional","affiliation":[{"name":"Department of Medical Social Sciences Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Institute for Innovations in Developmental Sciences Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Social Sciences Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Institute for Innovations in Developmental Sciences Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9511-2299","authenticated-orcid":false,"given":"Lauren S.","family":"Wakschlag","sequence":"additional","affiliation":[{"name":"Department of Medical Social Sciences Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Institute for Innovations in Developmental Sciences Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian L.","family":"Wiggins","sequence":"additional","affiliation":[{"name":"San Diego State University\/University of California San Diego Joint Doctoral Program in Clinical Psychology  San Diego California USA"},{"name":"Department of Psychology San Diego State University  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.7.1235"},{"key":"e_1_2_10_3_1","volume-title":"Manual for the child behavior checklist\/2\u20103 and 1992 profile","author":"Achenbach T. 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