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Further, not all individuals who experience victimisation will later engage in self\u2010harm, suggesting the influence of other factors. The present study examined whether perceived victimisation is associated with self\u2010harm during young adulthood while adjusting for confounders such as peer victimisation and mental health difficulties in adolescence. Additionally, we investigated whether genetic susceptibility for mental health difficulties moderates this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants were from the Quebec Longitudinal Study of Child Development (1998\u20132023); a population\u2010based birth cohort from the Canadian province of Quebec, with victimisation and self\u2010harm measures in young adulthood (sample 1;\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a01235), and who provided blood samples and had been genotyped (sample 2;\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0552). At 20\u00a0years old, they were asked how often they had experienced forms of victimisations in the past 12\u00a0months (e.g., insulted you, put you down in front of others) without specifying the perpetrator. At 20\u201325\u00a0years old, participants reported self\u2010harm. Polygenic scores (PGSs) for depression, attention deficit hyperactivity disorder (ADHD) and suicide attempt were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 17.2% (sample 1) participants reported self\u2010harm at age 20\u201325\u00a0years. Victimisation was associated with self\u2010harm (OR\u00a0=\u00a01.66, 95% CI\u00a0=\u00a01.45, 1.89, for each standard deviation increase in victimisation), even after adjusting for confounders, for example, victimisation and mental health in adolescence (OR\u00a0=\u00a01.53, 95% CI\u00a0=\u00a01.26, 1.86). In sample 2, PGSs for depression and suicide attempt (not ADHD) were associated with self\u2010harm as well as victimisation in young adulthood, and none moderated the association between victimisation and self\u2010harm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Regardless of genetic susceptibility indexed by PGSs, young adult exposed to victimisation are at higher risk of self\u2010harm. Continuing efforts to prevent victimisation beyond childhood\/adolescence and into young adulthood may contribute to reducing self\u2010harm risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcv2.70061","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:41:48Z","timestamp":1769060508000},"source":"Crossref","is-referenced-by-count":0,"title":["Young adult self\u2010harm: The role of victimisation and polygenic risk in a population\u2010based longitudinal study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3213-2721","authenticated-orcid":false,"given":"Filip","family":"Marzecki","sequence":"first","affiliation":[{"name":"Institute of Psychiatry, Psychology &amp; Neuroscience King's College London  London UK"},{"name":"Department of Psychiatry McGill University &amp; Douglas Mental Health University Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Ouellet\u2010Morin","sequence":"additional","affiliation":[{"name":"School of Criminology &amp; the Research Center of the Montreal Mental Health University Institute University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena M. 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