{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:06:21Z","timestamp":1773029181293,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCPP Advances"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Affective dysregulation (AD) in children is characterized by irritability, anger, and frequent intense temper outbursts. Considerable evidence implies altered processing of frustration about missed rewards, but few studies investigated the preceding and thus potentially predictive reward anticipation and initial delivery processing in children with AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 103 children aged 8\u201312\u00a0years (50 with AD and 53 without AD) were examined during a monetary reward anticipation task with event\u2010related potential (ERP) components resolving reward anticipation (cue\u2010CNV [Contingent Negative Variation]) and reward delivery phases (Reward Positivity and Feedback\u2010Related Negativity). All components were analyzed by repeated measures analysis of variance. Regression analyses also evaluated the associations between those ERP components and dimensional AD symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Children with AD showed attenuated anticipatory reward processing compared to No\u2010ADs. The CNV at fronto\u2010central site (FCz) showed a significant group effect (No\u2010AD\u00a0&gt;\u00a0AD,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017). Post\u2010hoc test showed that this group difference was stronger for the cue monetary condition (monetary cue:\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007,\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.56, verbal cue:\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.901,\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.16), and that only the No\u2010AD group showed a significant difference between conditions (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). No significant effects were obtained for the delivery phase. Regression analysis showed that a reduced anticipatory CNV at FCz significantly explained AD symptoms, and that anger\/irritability and anxiety\/depressive symptoms predicted a reduced anticipatory CNV at FCz.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This neurophysiological characterization of reward anticipation and delivery in children with AD demonstrates altered neural activity in AD during anticipation of reward rather than following the delivery (or omission) of the reward itself. Our results highlight that altered reward anticipation in AD can occur outside frustration\u2010prone tasks or settings, and underline the important role of both anger\/irritability and anxiety\/depressive symptoms in the pathophysiology of AD for atypical reward anticipation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcv2.70102","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:17:15Z","timestamp":1773026235000},"source":"Crossref","is-referenced-by-count":0,"title":["Reward processing in children with affective dysregulation"],"prefix":"10.1002","author":[{"given":"Pascal\u2010M.","family":"Aggensteiner","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim\/Heidelberg University  Mannheim Germany"},{"name":"German Center for Mental Health (DZPG)  partner site Mannheim\u2010Heidelberg\u2010Ulm 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Central Institute of Mental Health Medical Faculty Mannheim\/Heidelberg University  Mannheim Germany"},{"name":"German Center for Mental Health (DZPG)  partner site Mannheim\u2010Heidelberg\u2010Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Igel","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim\/Heidelberg University  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Hohmann","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy and Psychosomatics University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"D\u00f6pfner","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy Medical Faculty University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veit","family":"Roessner","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neurophysiology Department of Child and Adolescent Psychiatry Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"German Center for Child and Adolescent Health (DZKJ)  partner site Leipzig\u2010Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Beste","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neurophysiology Department of Child and Adolescent Psychiatry Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"German Center for Child and Adolescent Health (DZKJ)  partner site Leipzig\u2010Dresden 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