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Irritability was measured longitudinally at ages 7, 9, and 11. Adolescents self\u2010reported on anxiety, depression, and externalizing symptoms at age 13\u201320. Latent growth mixture modeling examined classes of irritability. Bayesian kernel machine regression (BKMR) examined unique and shared effects of stress components on class assignment and to continuously measured irritability at individual age points (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0472). Causal mediation tested if irritability mediated any stress\u2010related mental health problems.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Latent growth mixture modeling identified high and low irritability classes. A positive joint mixture effect of stressors on irritability was detected, with additive contributions from intimate partner violence, material hardship, perceived stress, and maternal demoralization. Intimate partner violence independently predicted high irritability over time and irritability at age 7, and maternal perceived stress independently predicted irritability at age 11. Neither childhood irritability nor early stress predicted self\u2010reported adolescent mental health symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early exposure to familial stressors are risk markers for childhood irritability. Interventions targeting intimate partner violence and co\u2010occurring stressors could help mitigate persistent irritability, a well\u2010known public health concern related to children's development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcv2.70153","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:20:09Z","timestamp":1786342809000},"source":"Crossref","is-referenced-by-count":0,"title":["Discrete components of stress impact trajectories of childhood irritability but not adolescent mental health outcomes"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3936-9708","authenticated-orcid":false,"given":"Mariah","family":"DeSerisy","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Health The Ohio State University  Columbus Ohio USA"},{"name":"Department of Psychiatry Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Health The Ohio State University  Columbus Ohio USA"},{"name":"Division of Child and Adolescent Psychiatry New York State Psychiatric Institute  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob W.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Division of Child and Adolescent Psychiatry New York State Psychiatric Institute  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1214-1965","authenticated-orcid":false,"given":"David","family":"Pagliaccio","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Division of Child and Adolescent Psychiatry New York State Psychiatric Institute  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie B.","family":"Herbstman","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences Mailman School of Public Health Columbia University  New York New York USA"},{"name":"Columbia Center for Children's Environmental Health Mailman School of Public Health Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley S.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Institute for the Developing Mind Children's Hospital Los Angeles  Los Angeles California USA"},{"name":"Department of Psychiatry Keck School of Medicine at the University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederica P.","family":"Perera","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences Mailman School of Public Health Columbia University  New York New York USA"},{"name":"Columbia Center for Children's Environmental Health Mailman School of Public Health Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Rauh","sequence":"additional","affiliation":[{"name":"Columbia Center for Children's Environmental Health Mailman School of Public Health Columbia University  New York New York USA"},{"name":"Heilbrunn Department of Population and Family Health Mailman School of Public Health Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Margolis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Health The Ohio State University  Columbus Ohio USA"},{"name":"The Child Mind Institute  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Manual for the ASEBA school\u2010age forms and profiles","author":"Achenbach T. 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