{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:38:18Z","timestamp":1792604298282,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018775","name":"Danish Foundation TrygFonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCPP Advances"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Children of parents with severe mental illness are at markedly increased risk of developing psychiatric disorders themselves. Interventions that target family\u2010related risk and protective factors may represent a promising approach in preventive psychiatry. This study evaluated the long\u2010term effects of the VIA Family intervention, a family\u2010based program designed for children at familial risk of severe mental illness and their families.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a 2.5\u2010year follow\u2010up of a randomized clinical trial comparing the VIA Family intervention with treatment as usual (TAU). Eligible participants were families with children aged 6\u201312\u00a0years at baseline and at least one biological parent with a current or past severe mental illness. Families in the intervention arm participated in VIA Family for 1.5\u00a0years. The primary outcome was child mental health, assessed with the Strengths and Difficulties Questionnaire (SDQ). Secondary outcomes were child global functioning and the quality of the home environment (support and stimulation). Trial registration:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      (NCT06218693).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At follow\u2010up, 65 out of 95 families (68% retention) participated, including 77 children. The estimated treatment difference for SDQ was \u22120.23 (95% CI: \u22123.11 to 2.66), indicating no measurable long\u2010term impact of the intervention on child mental health compared to TAU. No significant differences emerged between intervention and TAU groups for the secondary outcomes, changes in global functioning and home environment quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings highlight the challenges of achieving significant and specific impacts with interventions for families with children at familial risk for the development of mental illnesses. The results emphasize the need for further research to optimize family\u2010based programs for familial high\u2010risk populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcv2.70178","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:42:32Z","timestamp":1792600952000},"source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term effects of an intervention for families with parental severe mental illness\u2014A 2.5\u2010year RCT follow\u2010up"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4887-6672","authenticated-orcid":false,"given":"Anne D.","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Child and Adolescent Mental Health Center Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida C.\u00a0T.","family":"Gj\u00f8de","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Center Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mala","family":"Moszkowicz","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Center Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma P.","family":"Frostholm","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Center Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan S.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Center Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Forman","sequence":"additional","affiliation":[{"name":"Section of Biostatistics Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete","family":"Nordentoft","sequence":"additional","affiliation":[{"name":"Copenhagen Research Center for Mental Health \u2013 CORE Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne A.\u00a0E.","family":"Thorup","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Center Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Manual for ASEBA school\u2010age forms & profiles","author":"Achenbach T. 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