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Gamma\u2010aminobutyric acid (GABA) is known to mediate I responses in the central nervous system by interacting with GABA signaling receptors. In this context, several recent investigations suggest that imbalances in the GABAergic neurotransmission system may be implicated in the development of ASD as well as several other neurodevelopmental disorders, including Fragile X syndrome (FXS) and Rett syndrome. This review initially expounds the functional role of the GABAergic system in the mature brain and during neurodevelopment. This will be followed by discussions concerning the impact of deficiencies in the system on ASD and the other above\u2010mentioned neurodevelopment disorders. Finally, the connections between these deficiencies and behavioral features observed in the clinic will be considered.<\/jats:p>","DOI":"10.1002\/jdn.10005","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T19:30:18Z","timestamp":1578425418000},"page":"73-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The role of GABAergic neural circuits in the pathogenesis of autism spectrum disorder"],"prefix":"10.1002","volume":"80","author":[{"given":"Jing","family":"Di","sequence":"first","affiliation":[{"name":"Department of Neurology David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics the Second Xiangya Hospital Central South University Changsha P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"O\u2019Hara","sequence":"additional","affiliation":[{"name":"Department of Biology University of Kentucky Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Alberts","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences LaGuardia CC CUNY New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Yunnan University of Chinese Medicine Kunming P.R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurochemistry New York State Institute for Basic Research in Developmental Disabilities New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2346"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.05.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-0134"},{"issue":"11","key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1136\/ard.2008.089060","article-title":"The TRAF1\/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis","volume":"67","author":"Albers H. 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