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Early weaning (EW)\u00a0is a postnatal stress model consisting of interruption of lactation and maternal care. The 5HT\u2010system has been associated with neurobehavioral modulations promoted by ELS. Thus, the present work aims to investigate the effects of early weaning on feeding behavior and serotonergic system of juvenile male rats. For this, rats were submitted to early (PND15) or natural (PND30) weaning and had the body weight, food intake in circadian phases, and food intake in response to fenfluramine assessed. mRNA expression of serotoninergic receptors (5HT1A and 5HT2C) and transporter (SERT) was assessed in the hypothalamus and brainstem, as well as NPY and POMC mRNA expression in hypothalamus. The results show that early weaning promoted changes in the percentage of weight gain during lactation period and increase in body weight at PND40. It was also observed that EW promoted increase and decrease in food intake in light and dark phase, respectively, and leads to a decreased action of fenfluramine on inhibition of food intake. In addition, early weaning promoted increased NPY and SERT mRNA expression in the hypothalamus and 5HT2C in the brainstem. Together, the data indicate that the stress caused by early weaning impairs the eating behavior of juvenile male rats through hypofunction of the 5HT\u2010system.<\/jats:p>","DOI":"10.1002\/jdn.10018","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T15:28:24Z","timestamp":1582298904000},"page":"209-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Early weaning modulates eating behavior and promotes hypofunction of the serotonergic (5HT) system in juvenile male rats"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0255-1725","authenticated-orcid":false,"given":"Gabriel Ara\u00fajo","family":"Tavares","sequence":"first","affiliation":[{"name":"Graduate Program of Nutrition Federal University of Pernambuco Recife Brazil"},{"name":"Nantes Universit\u00e9, INRAE, UMR 1280, PhAN Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5688-3995","authenticated-orcid":false,"given":"Larissa Cavalcanti","family":"do Amaral Almeida","sequence":"additional","affiliation":[{"name":"Graduate Program of Neuropsychiatry and Behavioral Sciences Federal University of Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5262-5948","authenticated-orcid":false,"given":"Julliet Ara\u00fajo","family":"de Souza","sequence":"additional","affiliation":[{"name":"Graduate Program of Neuropsychiatry and Behavioral Sciences Federal University of Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8474-8830","authenticated-orcid":false,"given":"Felipe Leit\u00e3o","family":"de Souza","sequence":"additional","affiliation":[{"name":"Graduate Program of Nutrition Federal University of Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6107-5047","authenticated-orcid":false,"given":"Glauber Rud\u00e1","family":"Feitosa Braz","sequence":"additional","affiliation":[{"name":"Graduate Program of Neuropsychiatry and Behavioral Sciences Federal University of Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2401-5947","authenticated-orcid":false,"given":"Bruna Times","family":"Silva","sequence":"additional","affiliation":[{"name":"Graduate Program of Nutrition Federal University of Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-7192","authenticated-orcid":false,"given":"Andresa Mayara","family":"da Silva Santos","sequence":"additional","affiliation":[{"name":"Graduate Program of Nutrition Federal University of Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6883-9476","authenticated-orcid":false,"given":"Cl\u00e1udia Jacques","family":"Lagranha","sequence":"additional","affiliation":[{"name":"Graduate Program of Neuropsychiatry and Behavioral Sciences Federal University of Pernambuco Recife Brazil"},{"name":"Academic Center of Vit\u00f3ria\u2010CAV Federal University of Pernambuco Vit\u00f3ria de Santo Ant\u00e3o Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-7344","authenticated-orcid":false,"given":"Sandra Lopes","family":"de Souza","sequence":"additional","affiliation":[{"name":"Graduate Program of Nutrition Federal University of Pernambuco Recife Brazil"},{"name":"Graduate Program of Neuropsychiatry and Behavioral Sciences Federal University of Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/glia.23267","article-title":"Glial hypothalamic inhibition of GLUT2 expression alters satiety, impacting eating behavior","volume":"66","author":"Barahona M. 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