{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T20:53:53Z","timestamp":1768251233082,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T00:00:00Z","timestamp":1585094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20151420"],"award-info":[{"award-number":["BK20151420"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771628"],"award-info":[{"award-number":["81771628"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the role of stromal cell\u2010derived factor 1 (SDF\u20101) and C\u2010X\u2010C chemokine receptor type 4 (CXCR\u20104) in the premature brain with white matter damage (WMD) undergoing treatment with human umbilical cord mesenchymal stem cells (hUC\u2010MSCs) and recombinant human erythropoietin (rhEPO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Design<\/jats:title><jats:p>Three\u2010day\u2010old Sprague\u2010Dawley (SD) rats were randomly divided into sham operation group, hypoxia\u2010ischemia (HI) group, rhEPO treated HI group, hUC\u2010MSCs treated HI group, and rhEPO\u00a0+\u00a0hUC\u2010MSCs treated HI group. WMD was established in all groups except the Sham group. SDF\u20101 and CXCR\u20104 levels in each group were detected at postnatal day (P) 5, P7, and P14. Pathological changes were assessed via HE staining at P14 and neuroethological tests were performed at P28.<\/jats:p><\/jats:sec><jats:sec><jats:title>Observations and Conclusions<\/jats:title><jats:p>The rhEPO and hUC\u2010MSCs intervention reduced injury area, increased body weight at P7, and improved neurobehavioral scores at P28. Furthermore, their combined use proved even more beneficial. SDF\u20101 levels in the rhEPO group were higher than those in the other groups and highest in the hUC\u2010MSCs\u00a0+\u00a0rhEPO group (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). SDF\u20101 levels in the hUC\u2010MSCs\u00a0+\u00a0rhEPO and rhEPO groups were increased at P5 and reached a peak at P7. CXCR\u20104 levels in the hUC\u2010MSCs group were higher than those in the other groups and highest in the hUC\u2010MSCs\u00a0+\u00a0rhEPO group (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). CXCR\u20104 levels were also increased at P5 and highest at P14.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>hUC\u2010MSCs\u00a0+\u00a0rhEPO might reduce nerve cell damage and improve neurobehavioral development, in connection with increased SDF\u20101 and CXCR\u20104 expression, in premature rats with WMD due to hypoxic\u2013ischemic injury.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jdn.10021","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T15:00:25Z","timestamp":1582902025000},"page":"247-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Elevation of stromal cell\u2010derived factor 1 and C\u2010X\u2010C chemokine receptor type 4 in white matter damage treatment with recombinant human erythropoietin and human umbilical cord mesenchymal stem cells in a rat model of preterm birth"],"prefix":"10.1002","volume":"80","author":[{"given":"Liping","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Pediatrics Zhongda Hospital Southeast University Nanjing China"},{"name":"Teaching and Research Section of Pediatrics Medical College Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Xuanwu Hospital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Zhongda Hospital Southeast University Nanjing China"},{"name":"Teaching and Research Section of Pediatrics Medical College Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Bai","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Gansu Provincial Maternity and Child\u2010care Hospital Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Zhongda Hospital Southeast University Nanjing China"},{"name":"Teaching and Research Section of Pediatrics Medical College Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Zhongda Hospital Southeast University Nanjing China"},{"name":"Teaching and Research Section of Pediatrics Medical College Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Zhongda Hospital Southeast University Nanjing China"},{"name":"Teaching and Research Section of Pediatrics Medical College Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Zhongda Hospital Southeast University Nanjing China"},{"name":"Teaching and Research Section of Pediatrics Medical College Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0377-2471","authenticated-orcid":false,"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Zhongda Hospital Southeast University Nanjing China"},{"name":"Teaching and Research Section of Pediatrics Medical College Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,25]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"46","article-title":"Stromal cell\u2010derived factor\u20101 mediates stem cell homing and tissue regeneration","volume":"3","author":"Askari A. 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