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Pregnant rats received VPA (600\u00a0mg\/kg\/i.p.) once at 12.5 gestational days for autism\u2010like symptom induction in offspring. After the delivery single male and single female offspring from each mother were randomly selected for behavioral test (anxiety, pain response, pleasure, and motor function) at 60th day adulthood (<jats:italic>n<\/jats:italic>\u00a0=\u00a07). Offspring received prenatal PGB (15 &amp; 30\u00a0mg\/kg\/i.p.) during gestational days 9.5 to 15.5 either alone or in combination with VPA (PGB15, PGB30, PGB15\u00a0+\u00a0VPA, and PGB30\u00a0+\u00a0VPA). Control offspring received normal saline during the same period. The result showed that prenatal VPA exposure was associated with autism\u2010like behaviors in rat offspring. PGB treatment during the gestational period revealed significant reduction in sucrose preference test and anxiety in elevated plus maze and open field test in offspring. Also, PGB treatments exhibited a dose\u2010dependent increase in pain threshold in prenatally VPA exposed rats in tail\u2010flick and hot plate test. Also, there was a sex\u2010related significant impairment in motor function in beam balance and open field test, and male rats were affected more than females. However, no significant sex differences in sucrose preference and pain sensitivity were observed in prenatal PGB\u2010treated rat offspring. In conclusion, prenatal exposure to VPA increased the risk of autism\u2010like behaviors in the offspring rats, and PGB treatment during the gestational period was associated with some beneficial effects, including anxiety reduction and motor impairment in autism\u2010like symptoms in rat offspring.<\/jats:p>","DOI":"10.1002\/jdn.10046","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T06:20:52Z","timestamp":1593152452000},"page":"500-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prenatal pregabalin is associated with sex\u2010dependent alterations in some behavioral parameters in valproic acid\u2010induced autism in rat offspring"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4011-7364","authenticated-orcid":false,"given":"Manzumeh","family":"Shamsi Meymandi","sequence":"first","affiliation":[{"name":"Pathology and Stem Cells Research Center Kerman Medical School Kerman University of Medical Sciences Kerman Iran"},{"name":"Neuroscience Research Center Institute of Neuropharmacology Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7999-9934","authenticated-orcid":false,"given":"Gholamreza","family":"Sepehri","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Institute of Neuropharmacology Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3211-8911","authenticated-orcid":false,"given":"Amirhossein","family":"Moslemizadeh","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Shahid Bahonar University of Kerman Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9557-6966","authenticated-orcid":false,"given":"SeyyedSajjad","family":"Vakili Shahrbabaki","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Shahid Bahonar University of Kerman Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8818-0170","authenticated-orcid":false,"given":"Hamideh","family":"Bashiri","sequence":"additional","affiliation":[{"name":"Physiology Research Center Department of Physiology and Pharmacology Medical School Institute of Neuropharmacology Kerman University of Medical Sciences Kerman Iran"},{"name":"Department of Physiology and Pharmacology Sirjan School of Medical Sciences Sirjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362645"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2019.04.014"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/916178"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.5152\/balkanmedj.2015.15742","article-title":"Neuroprotective effects of pregabalin on cerebral ischemia and reperfusion","volume":"33","author":"Asci S.","year":"2016","journal-title":"Balkan Medical Journal"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnhum.2012.00042","article-title":"Pregabalin effects on neural response to emotional faces","volume":"6","author":"Aupperle R. 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