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This study explored the co\u2010existence effect of environmental enrichment (EE) and restraint stress (RS) on innate anxiety and depressive\u2010like behavior in adolescent mice. Male ICR mice were treated with daily EE and RS (4\u00a0h\/d or 8\u00a0h\/d) for 2 or 4\u00a0weeks from early adolescence (postnatal day 30) and emotional behaviors were evaluated 24\u00a0h after the end of treatment. 4 weeks of 8\u00a0h RS treatment decreased immobility time in forced swimming test, demonstrating an antidepressant\u2010like effect. For 2\u00a0weeks of treatment, 8\u00a0h RS significantly reduced the time spent in the lighted compartment of the light\u2010dark box, indicating an increased anxiety level. These results show that under the present experimental design, RS treatment with different duration could have different effect on mice emotion\u2010related behavior, but there was no interaction between EE and RS.<\/jats:p>","DOI":"10.1002\/jdn.10061","type":"journal-article","created":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T10:20:10Z","timestamp":1599301210000},"page":"730-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Concurrent environmental enrichment and chronic restraint stress: Effects on innate anxiety and depressive\u2010like behavior in male adolescent mice"],"prefix":"10.1002","volume":"80","author":[{"given":"Yu","family":"Mao","sequence":"first","affiliation":[{"name":"Scientific Research Center Yunnan University of Chinese Medicine Kunming P.R. 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