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Exposure to anesthetics leads to neurotoxicity and apoptosis of nerve cells, which in turn induces cognitive dysfunction. Although most of the data came from animal studies, general anesthetics have been shown to have adverse effects on cognitive function in infants and young children in recent years. This concern has led to a number of retrospective studies that observed an association between general anesthesia in pregnant women and neurobehavioral problems in fetuses or offspring. Every year, many pregnant women undergo non\u2010obstetric anesthesia due to various reasons such as traffic accidents, fetal interventions, acute appendicitis, symptomatic cholelithiasis, and trauma. A matter of concern for these pregnant women is whether anesthesia has a detrimental effect on fetal brain development in the womb and whether the fetus has cognitive impairment after birth. In humans, the association of anesthetic exposure in infants with the long\u2010term impairment of neurologic functions has been reported in several retrospective clinical studies. Recently, we have found that sevoflurane anesthesia during pregnancy in mice\u2010induced cognitive impairment in the offspring by causing iron deficiency and inhibiting myelinogenesis. Sevoflurane is a commonly used general anesthetic in the hospitals, which can induce neurotoxicity and cause cognitive impairment in fetuses, infants, children, and adults. However, the exact mechanism of sevoflurane\u2010induced damage to the central nervous system (CNS) is not fully understood. Based on our recent results, this paper reviewed the effects of sevoflurane on cognitive impairment and pathological changes such as neurogenesis, neuronal apoptosis, and iron metabolism dysfunction in the offspring.<\/jats:p>","DOI":"10.1002\/jdn.10080","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T23:51:11Z","timestamp":1606866671000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prenatal sevoflurane exposure: Effects of iron metabolic dysfunction on offspring cognition and potential mechanism"],"prefix":"10.1002","volume":"81","author":[{"given":"Yong","family":"Zuo","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Iron Metabolism College of Life Science Hebei Normal University Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhong","family":"Chang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Iron Metabolism College of Life Science Hebei Normal University Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0924-2538","authenticated-orcid":false,"given":"Anand","family":"Thirupathi","sequence":"additional","affiliation":[{"name":"Faculty of Sports Science Ningbo University Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7308-3239","authenticated-orcid":false,"given":"Zhenhua","family":"Shi","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Iron Metabolism College of Life Science Hebei Normal University Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14024"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12691"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000475928"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.09.006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001161"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13425"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.01.016"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.111"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-018-2545-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23652"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20412"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2019.09.001"},{"issue":"1","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12871-018-0553-1","article-title":"Mesenchymal stromal cells attenuate sevoflurane\u2010induced apoptosis in human neuroglioma H4 cells","volume":"18","author":"Cheng Y.","year":"2018","journal-title":"BMC Anesthesiology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001470"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000037"},{"key":"e_1_2_11_17_1","first-page":"3971","article-title":"The postoperative effect of sevoflurane inhalational anesthesia on cognitive function and inflammatory response of pediatric patients","volume":"22","author":"Fan C. 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