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We evaluated the effects of gallic acid on hyperlocomotion, acetylcholinesterase activity, and oxidative stress in an animal model of ketamine\u2010induced mania. Rats were pretreated orally with vehicle, gallic acid (50 or 100\u00a0mg\/kg), or lithium (45\u00a0mg\/kg twice a day) for 14\u00a0days. Between days 8 and 14, the animals also received ketamine (25\u00a0mg\/kg) or saline daily. On the 15th day, hyperlocomotion was assessed, following which the animals were euthanized, and brains were collected. Results showed that ketamine\u2010induced hyperlocomotion and caused oxidative damage by increasing reactive oxygen species levels, lipid peroxidation, and nitrite levels, and decreasing the total thiol content and the activities of catalase, superoxide dismutase, and glutathione peroxidase in the brain. Pretreatment with gallic acid and lithium prevented hyperlocomotion and brain oxidative damage. Further, ketamine increased the acetylcholinesterase activity in the hippocampus and striatum, whereas gallic acid and lithium ameliorated this alteration. Thus, gallic acid may provide effective protection against manic\u2010like behavior by reducing oxidative stress and preventing cholinergic signaling dysfunction in the brain regions involved in emotion regulation.<\/jats:p>","DOI":"10.1002\/jdn.10086","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T18:52:29Z","timestamp":1609786349000},"page":"167-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Gallic acid protects cerebral cortex, hippocampus, and striatum against oxidative damage and cholinergic dysfunction in an experimental model of manic\u2010like behavior: Comparison with lithium effects"],"prefix":"10.1002","volume":"81","author":[{"given":"V\u00e2nia Machado","family":"Recart","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioqu\u00edmica e Bioprospec\u00e7\u00e3o\u2014Laborat\u00f3rio de Neuroqu\u00edmica, Inflama\u00e7\u00e3o e C\u00e2ncer Centro de Ci\u00eancias Qu\u00edmicas, Farmac\u00eauticas e de Alimentos, Universidade Federal de Pelotas Campus Universit\u00e1rio S\/N Pelotas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1587-1880","authenticated-orcid":false,"given":"Luiza","family":"Spohr","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioqu\u00edmica e Bioprospec\u00e7\u00e3o\u2014Laborat\u00f3rio de Neuroqu\u00edmica, Inflama\u00e7\u00e3o e C\u00e2ncer Centro de Ci\u00eancias Qu\u00edmicas, Farmac\u00eauticas e de Alimentos, Universidade Federal de Pelotas Campus Universit\u00e1rio S\/N Pelotas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2181-3591","authenticated-orcid":false,"given":"Mayara Sandrielly Pereira","family":"Soares","sequence":"additional","affiliation":[{"name":"Programa de 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