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Behavioral symptoms, including impaired social interaction and increased repetitive or stereotypic movements, are hallmark characteristics\u00a0of autism. Animal models are research tools used to study the\u00a0biology of the disease\u00a0and to develop new therapeutic approaches. The\u00a0complexity of\u00a0the etiology of autism makes it challenging to develop a comprehensive animal model that accurately mimics different clinical\u00a0aspects of autism. Here, we reviewed the literature on modeling and behavioral assessment of autism in the rodent, and focused on\u00a0ASD behavioral phenotypes that can be modeled in rodents. These animal models can be effective in gaining a better understanding of the pathophysiology of the disease.<\/jats:p>","DOI":"10.1002\/jdn.10096","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T16:59:04Z","timestamp":1613062744000},"page":"221-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["An overview of modeling and behavioral assessment of autism in the rodent"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6272-056X","authenticated-orcid":false,"given":"Sara","family":"Haratizadeh","sequence":"first","affiliation":[{"name":"Department of Anatomical Sciences Afzalipour School of Medicine Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6971-6144","authenticated-orcid":false,"given":"Mahdieh","family":"Parvan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Afzalipour School of Medicine Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Student Research Committee Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-5849","authenticated-orcid":false,"given":"Mohammad","family":"Shabani","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Institute of Neuropharmacology Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1543-6240","authenticated-orcid":false,"given":"Masoumeh","family":"Nozari","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Afzalipour School of Medicine Kerman University of Medical Sciences Kerman Iran"},{"name":"Neuroscience Research Center Institute of Neuropharmacology Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"50978","article-title":"Marble burying and nestlet shredding as tests of repetitive, compulsive\u2010like behaviors in mice","volume":"82","author":"Angoa\u2010P\u00e9rez M.","year":"2013","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmod.2005.05.004"},{"issue":"1","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13229-018-0222-8","article-title":"Autism spectrum disorder: Prospects for treatment using gene therapy","volume":"9","author":"Benger M.","year":"2018","journal-title":"Molecular Autism"},{"key":"e_1_2_9_5_1","volume-title":"Current protocols in pharmacology","author":"Bey A. 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