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Today, with the viewpoint of an increasingly aging society, the number of patients with neurodegenerative diseases and sociomedical burdens will spread intensely. During the last decade, stem cell technology has attracted great attention for treating neurodegenerative diseases worldwide because of its unique attributes. As acknowledged, there are several categories of stem cells being able to proliferate and differentiate into various cellular lineages, highlighting their significance in the context of regenerative medicine. In preclinical models, stem cell therapy using mesenchymal stem\/stromal cells (MSCs), hematopoietic stem cells (HSCs), and neural progenitor or stem cells (NPCs or NSCs) along with pluripotent stem cells (PSCs)\u2010derived neuronal cells could elicit desired therapeutic effects, enabling functional deficit rescue partially. Regardless of the noteworthy progress in our scientific awareness and understanding of stem cell biology, there still exist various challenges to defeat. In the present review, we provide a summary of the therapeutic potential of stem cells and discuss the current status and prospect of stem cell strategy in neurodegenerative diseases, in particular, AD, PD, ALS, and HD.<\/jats:p>","DOI":"10.1002\/jdn.10101","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T10:20:45Z","timestamp":1614680445000},"page":"291-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Stem cell in neurodegenerative disorders; an emerging strategy"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-1872","authenticated-orcid":false,"given":"Milad","family":"Ahani\u2010Nahayati","sequence":"first","affiliation":[{"name":"Department of Tissue Engineering and Applied Cell Science School of Advanced Technologies in Medicine Shahid Beheshti University of Medical Science Tehran 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