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Changes in neurotransmitter receptors have been associated with these alterations, but little is known on how early hypoxia influences the expression and function of metabotropic glutamate (mGlu) receptors in adult life. This is an important issue because mGlu receptors are implicated in mechanisms of synaptic plasticity. Here, we examined the expression of mGlu1, mGlu5, and mGlu2\/3 receptor subtypes in the hippocampus, nucleus accumbens, prefrontal cortex, and dorsal striatum in 6\u2010month old Wistar rats (a) born by vaginal delivery; (b) born by caesarean section; and (c) born by caesarean section followed by 20\u00a0min of asphyxia. Unexpectedly, we found a large reduction of mGlu1\u03b1 protein levels in the hippocampus of rats born by caesarean section regardless of the presence of asphyxia. No changes in mGlu1\u03b1 receptor protein levels were found in the other brain regions. Levels of mGlu5 and mGlu2\/3 receptors and levels of GluA2\/3 and GluN1 subunits of AMPA and NMDA receptors did not differ among the three groups of rats in any brain region. These results are consistent with previous findings showing that changes in mGlu1 receptors occur within the epigenetic programming caused by early\u2010life events.<\/jats:p>","DOI":"10.1002\/jdn.10105","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T03:49:27Z","timestamp":1616557767000},"page":"333-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Selective reduction in the expression of type\u20101 metabotropic glutamate receptors in the hippocampus of adult rats born by caesarean section"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-6587","authenticated-orcid":false,"given":"Anna Rita","family":"Zuena","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Casolini","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldina","family":"Venerosi","sequence":"additional","affiliation":[{"name":"Centre for Behavioural Science and Mental Health Istituto Superiore di Sanita Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Sebastiano","family":"Alem\u00e0","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Nicoletti","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Sapienza University of Rome Rome Italy"},{"name":"I.R.C.C.S. 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